Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells.
Antineoplastic Agents, Phytogenic
/ chemistry
Apoptosis
/ drug effects
Bone Neoplasms
/ genetics
Cell Cycle
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Epithelial-Mesenchymal Transition
/ drug effects
Humans
Matrix Metalloproteinases
Models, Biological
Osteosarcoma
/ genetics
Plant Extracts
/ chemistry
Salvia
/ chemistry
Signal Transduction
/ drug effects
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
MAPKs
MG-63 osteosarcoma
MMPs
Salvia clandestina L.
apoptosis
danshensu
epithelial-to-mesenchymal transition
phenolic compounds
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
25
02
2021
received:
16
12
2020
accepted:
23
03
2021
pubmed:
8
5
2021
medline:
15
12
2021
entrez:
7
5
2021
Statut:
ppublish
Résumé
Salvia clandestina L. is a wild perennial species present in the Salento area of Italy. Here, we examined the in vitro effects of an aqueous extract of S. clandestina L. on the MG-63 osteosarcoma cell line. The extract reduced osteosarcoma cell viability mainly by way of apoptosis, as we observed (1) upregulation of gene and protein expression of p53, cyclin-dependent kinase inhibitors p21
Identifiants
pubmed: 33960434
doi: 10.1111/nyas.14601
pmc: PMC8518948
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Plant Extracts
0
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
34-47Informations de copyright
© 2021 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences.
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