Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT-1 expression.
Animals
Cell Transdifferentiation
Endothelial Cells
/ metabolism
Extracellular Vesicles
/ metabolism
Gene Expression Regulation
Humans
Muscle, Smooth, Vascular
/ metabolism
Osteogenesis
Proto-Oncogene Proteins c-akt
/ genetics
Rats
Renal Insufficiency, Chronic
/ genetics
Transcription Factor Pit-1
/ genetics
Uremia
/ physiopathology
Vascular Calcification
/ metabolism
chronic kidney disease
exosomes
extracellular vesicles
uraemia
vascular calcification
vascular smooth muscle cells
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
01
04
2021
received:
13
01
2021
accepted:
13
04
2021
pubmed:
8
5
2021
medline:
2
10
2021
entrez:
7
5
2021
Statut:
ppublish
Résumé
Extracellular vesicles (EV) function as messengers between endothelial cells (EC) and vascular smooth muscle cells (VSMC). Since chronic kidney disease (CKD) increases the risk for vascular calcifications, we investigated whether EV derived from uraemic milieu-stimulated EC and derived from uraemic rats impact the osteogenic transdifferentiation/calcification of VSMC. For that purpose, human EC were treated with urea and indoxyl sulphate or left untreated. Experimental uraemia in rats was induced by adenine feeding. 'Uraemic' and control EV (EV
Identifiants
pubmed: 33960650
doi: 10.1111/jcmm.16572
pmc: PMC8184672
doi:
Substances chimiques
Transcription Factor Pit-1
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5602-5614Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 1340/1 2018
Organisme : Deutsche Forschungsgemeinschaft
ID : B03
Organisme : Deutsche Forschungsgemeinschaft
ID : C01
Organisme : Bundesministerium für Bildung und Forschung
ID : 03VP02991
Informations de copyright
© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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