Intracerebroventricular injection of propranolol blocked analgesic and neuroprotective effects of resveratrol following L
catalase enzyme
neuropathic pain
propranolol
resveratrol
superoxide dismutase enzyme
Journal
Journal of complementary & integrative medicine
ISSN: 1553-3840
Titre abrégé: J Complement Integr Med
Pays: Germany
ID NLM: 101313855
Informations de publication
Date de publication:
10 May 2021
10 May 2021
Historique:
received:
25
09
2020
accepted:
02
01
2021
pubmed:
8
5
2021
medline:
29
12
2021
entrez:
7
5
2021
Statut:
epublish
Résumé
Resveratrol as a natural polyphenolic agent can alleviate neuropathic pain symptoms. The mechanism of analgesic activity of resveratrol is far from clear. The current study examine whether analgesic activity of resveratrol is mediated by its neuroprotective and anti-oxidant activity in the neuropathic pain. We further examine whether analgesic activity of resveratrol is mediated by β-adrenoceptors in the brain. Neuropathic pain induced by L Resveratrol significantly decreased thermal allodynia (and not anxiety) in all experimental days. Additionally, resveratrol significantly increased NCV, and also normalized the disrupted Cat and SOD activities following neuropathic pain. Furthermore, propranolol significantly blocked the analgesic and neuroprotective effects of resveratrol. It is suggested that the analgesic effects of resveratrol is mediated by its neuroprotective and antioxidant activities in the neuropathic rats. Furthermore, propranolol blocked the analgesic and neuroprotective effects of resveratrol.
Identifiants
pubmed: 33962501
pii: jcim-2020-0393
doi: 10.1515/jcim-2020-0393
doi:
Substances chimiques
Analgesics
0
Neuroprotective Agents
0
Propranolol
9Y8NXQ24VQ
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
701-710Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
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