Maternal haemodynamics during labour epidural analgesia with and without adrenaline.
adrenaline
epidural analgesia
epinephrine
haemodynamics
labour
Journal
Scandinavian journal of pain
ISSN: 1877-8879
Titre abrégé: Scand J Pain
Pays: Germany
ID NLM: 101520867
Informations de publication
Date de publication:
26 10 2021
26 10 2021
Historique:
received:
17
11
2020
accepted:
15
03
2021
pubmed:
9
5
2021
medline:
15
12
2021
entrez:
8
5
2021
Statut:
epublish
Résumé
Labour is one of the most painful experiences in a woman's life. Epidural analgesia using low-concentration local anaesthetics and lipophilic opioids is the gold standard for pain relief during labour. Pregnancy in general, particularly labour, is associated with changes in maternal haemodynamic variables, such as cardiac output and heart rate, which increase and peak during uterine contractions. Adrenaline is added to labour epidural solutions to enhance efficacy by stimulating the α2-adrenoreceptor. The minimal effective concentration of adrenaline was found to be 2 μg mL This was a secondary analysis of a single-centre, randomised double-blind trial. Forty-one nulliparous women in labour requesting epidural analgesia were randomised to receive epidural solution of bupivacaine 1 mg mL After excluding three patients due to poor data quality and two due to a malfunctioning epidural catheter, 36 patients (18 in each group) were analysed. The addition of adrenaline to the solution had no significant effect on the temporal changes in peak systolic blood pressure (p The addition of 2 μg mL
Identifiants
pubmed: 33964196
pii: sjpain-2020-0176
doi: 10.1515/sjpain-2020-0176
doi:
Substances chimiques
Bupivacaine
Y8335394RO
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
680-687Informations de copyright
© 2021 Felix Haidl et al., published by De Gruyter, Berlin/Boston.
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