Within- and between-subject biological variation data for tumor markers based on the European Biological Variation Study.
biological variation
cancer
tumor markers
Journal
Clinical chemistry and laboratory medicine
ISSN: 1437-4331
Titre abrégé: Clin Chem Lab Med
Pays: Germany
ID NLM: 9806306
Informations de publication
Date de publication:
28 03 2022
28 03 2022
Historique:
received:
09
03
2021
accepted:
27
04
2021
pubmed:
9
5
2021
medline:
26
3
2022
entrez:
8
5
2021
Statut:
epublish
Résumé
Reliable biological variation (BV) data are required for the clinical use of tumor markers in the diagnosis and monitoring of treatment effects in cancer. The European Biological Variation Study (EuBIVAS) was established by the EFLM Biological Variation Working Group to deliver BV data for clinically important measurands. In this study, EuBIVAS-based BV estimates are provided for cancer antigen (CA) 125, CA 15-3, CA 19-9, carcinoembryonic antigen, cytokeratin-19 fragment, alpha-fetoprotein and human epididymis protein 4. Subjects from five European countries were enrolled in the study, and weekly samples were collected from 91 healthy individuals (53 females and 38 males; 21-69 years old) for 10 consecutive weeks. All samples were analyzed in duplicate within a single run. After excluding outliers and homogeneity analysis, the BVs of tumor markers were determined by CV-ANOVA on trend-corrected data, when relevant (Røraas method). Marked individuality was found for all tumor markers. CYFRA 21-1 was the measurand with the highest index of individuality (II) at 0.67, whereas CA 19-9 had the lowest II at 0.07. The CV This study provides updated BV estimates for several tumor markers, and the findings indicate that marked individuality is characteristic. The use of reference change values should be considered when monitoring treatment of patients by means of tumor markers.
Identifiants
pubmed: 33964202
pii: cclm-2021-0283
doi: 10.1515/cclm-2021-0283
doi:
Substances chimiques
Antigens, Neoplasm
0
Biomarkers, Tumor
0
Keratin-19
0
antigen CYFRA21.1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
543-552Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
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