Current Challenges for IDO2 as Target in Cancer Immunotherapy.
Animals
Antineoplastic Agents, Immunological
/ pharmacology
Autoimmunity
Biomarkers, Tumor
Disease Management
Disease Susceptibility
Enzyme Inhibitors
/ pharmacology
Gene Expression Regulation
/ drug effects
Humans
Immunotherapy
Indoleamine-Pyrrole 2,3,-Dioxygenase
/ antagonists & inhibitors
Inflammation
/ etiology
Molecular Targeted Therapy
/ methods
Neoplasms
/ drug therapy
Treatment Outcome
IDO2
NSCLC
PDAC
pseudoenzymes
tryptophan metabolism
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
03
2021
accepted:
01
04
2021
entrez:
10
5
2021
pubmed:
11
5
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Immune checkpoint inhibitors have revolutionized the clinical approach of untreatable tumors and brought a breath of fresh air in cancer immunotherapy. However, the therapeutic effects of these drugs only cover a minority of patients and alternative immunotherapeutic targets are required. Metabolism of l-tryptophan (Trp)
Identifiants
pubmed: 33968089
doi: 10.3389/fimmu.2021.679953
pmc: PMC8097162
doi:
Substances chimiques
Antineoplastic Agents, Immunological
0
Biomarkers, Tumor
0
Enzyme Inhibitors
0
IDO2 protein, human
0
Indoleamine-Pyrrole 2,3,-Dioxygenase
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
679953Informations de copyright
Copyright © 2021 Mondanelli, Mandarano, Belladonna, Suvieri, Pelliccia, Bellezza, Sidoni, Carvalho, Grohmann and Volpi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Immunol Rev. 2010 Jul;236:243-64
pubmed: 20636821
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19961-6
pubmed: 21041655
CA Cancer J Clin. 2016 Jul;66(4):271-89
pubmed: 27253694
Gene. 2007 Jul 1;396(1):203-13
pubmed: 17499941
Oncoimmunology. 2014 Dec 15;3(10):e957994
pubmed: 25941578
Front Immunol. 2014 Nov 20;5:585
pubmed: 25477879
Curr Opin Struct Biol. 2017 Dec;47:95-104
pubmed: 28787627
J Immunol. 2010 Sep 15;185(6):3190-8
pubmed: 20720200
Clin Cancer Res. 2019 Jan 15;25(2):724-734
pubmed: 30266763
J Immunol. 2016 Jun 1;196(11):4487-97
pubmed: 27183624
Nat Immunol. 2016 Feb;17(2):132-9
pubmed: 26784254
Sci Signal. 2019 Aug 13;12(594):
pubmed: 31409758
Front Immunol. 2020 Jun 16;11:1185
pubmed: 32612606
FEBS J. 2020 Oct;287(19):4300-4309
pubmed: 32889786
Nat Immunol. 2011 Jul 31;12(9):870-8
pubmed: 21804557
Int J Tryptophan Res. 2017 Oct 09;10:1178646917735098
pubmed: 29051706
J Cell Mol Med. 2017 Jan;21(1):165-176
pubmed: 27696702
Nature. 2016 Mar 3;531(7592):47-52
pubmed: 26909576
Amino Acids. 2010 Jul;39(2):565-78
pubmed: 20140689
Int J Mol Sci. 2020 Aug 01;21(15):
pubmed: 32752186
EMBO Rep. 2020 Dec 3;21(12):e49756
pubmed: 33159421
Lancet Oncol. 2019 Aug;20(8):1083-1097
pubmed: 31221619
World J Gastrointest Oncol. 2020 Feb 15;12(2):173-181
pubmed: 32104548
Blood. 2008 Feb 15;111(4):2152-4
pubmed: 18045970
J Immunol. 2014 Mar 1;192(5):2082-2090
pubmed: 24489090
N Engl J Med. 2015 Oct 22;373(17):1627-39
pubmed: 26412456
Front Immunol. 2020 May 27;11:839
pubmed: 32536910
Cancer Sci. 2019 Oct;110(10):3061-3067
pubmed: 31444833
Eur J Med Chem. 2019 Jan 15;162:455-464
pubmed: 30469041
Sci Rep. 2018 Oct 29;8(1):15917
pubmed: 30374077
J Thorac Oncol. 2011 Feb;6(2):244-85
pubmed: 21252716
Nat Rev Immunol. 2004 Oct;4(10):762-74
pubmed: 15459668
Curr Opin Pharmacol. 2017 Aug;35:30-39
pubmed: 28554057
N Engl J Med. 2015 Jul 9;373(2):123-35
pubmed: 26028407
J Neurooncol. 2018 Sep;139(2):239-249
pubmed: 29667084
Cancer Res. 2017 Dec 15;77(24):6795-6811
pubmed: 29247038
Oncotarget. 2016 May 31;7(22):32329-40
pubmed: 27058624
Nature. 2014 Jul 10;511(7508):184-90
pubmed: 24930766
N Engl J Med. 2017 Jun 22;376(25):2415-2426
pubmed: 28636851
Int Immunol. 2014 Jul;26(7):357-67
pubmed: 24402311
Front Immunol. 2019 May 07;10:890
pubmed: 31134053
Cancer Cell. 2003 Dec;4(6):437-50
pubmed: 14706336
Amino Acids. 2014 Sep;46(9):2155-63
pubmed: 24875753
Front Immunol. 2015 Feb 03;6:34
pubmed: 25691885
Nat Rev Immunol. 2019 Mar;19(3):184-197
pubmed: 30718831
J Am Coll Surg. 2009 May;208(5):781-7; discussion 787-9
pubmed: 19476837