Association of inbreeding and regional equine leucocyte antigen homozygosity with the prevalence of insect bite hypersensitivity in Old Kladruber horse.
genomics
horse
inbreeding
inbreeding depression
insect bite hypersensitivity
pedigree
Journal
Animal genetics
ISSN: 1365-2052
Titre abrégé: Anim Genet
Pays: England
ID NLM: 8605704
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
accepted:
22
04
2021
pubmed:
11
5
2021
medline:
2
9
2021
entrez:
10
5
2021
Statut:
ppublish
Résumé
Inbreeding depression is the reduction of performance caused by mating of close relatives. In livestock populations, inbreeding depression has been traditionally estimated by regression of phenotypes on pedigree inbreeding coefficients. This estimation can be improved by utilising genomic inbreeding coefficients. Here we estimate inbreeding depression for insect bite hypersensitivity (IBH) prevalence, the most common allergic horse disease worldwide, in Old Kladruber horse. In a deep pedigree with 3214 horses (187 genotyped), we used a generalised linear mixed model with IBH phenotype from 558 horses examined between 1996 and 2009 (1368 records). In addition to the classical pedigree information, we used the single-step approach that enabled joint use of pedigree and genomic information to estimate inbreeding depression overall genome and equine leucocyte antigen (ELA) class II region. Significant inbreeding depression was observed in all models fitting overall inbreeding coefficients (odds ratio between 1.018 and 1.074, P < 0.05) with the exception of Kalinowski's new inbreeding (P = 0.0516). The increase of ELA class II inbreeding was significantly associated with increased prevalence of IBH (odds ratio 1.018; P = 0.027). However, when fitted jointly with the overall inbreeding coefficient, the effect of ELA class II inbreeding was not significant (odds ratio 1.016; P = 0.062). Overall, the higher ELA class II and/or overall inbreeding (pedigree or genomic) was associated with increased prevalence of IBH in Old Kladruber horses. The single-step approach provides an efficient use of all the available pedigree, genomic, and phenotype information for estimation of overall and regional inbreeding effects.
Identifiants
pubmed: 33970495
doi: 10.1111/age.13075
pmc: PMC8360196
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
422-430Subventions
Organisme : Ministry of Agriculture of the Czech Republic
ID : QK1910156
Organisme : Ministry of Agriculture of the Czech Republic
ID : MZE-RO0719
Organisme : Ministry of Agriculture of the Czech Republic
ID : QK1910320
Organisme : Croatian Science Foundation
ID : ANAGRAMS-IP-2018-01-8708
Organisme : BBSRC to The Roslin Institute
ID : BBS/E/D/30002275
Organisme : The University Of Edinburgh's Data-Driven Innovation Chancellor's Fellowship
Informations de copyright
© 2021 The Authors. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics.
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