PGI
Adult
Aged
Animals
Caco-2 Cells
Case-Control Studies
Colitis
/ chemically induced
Dextran Sulfate
/ adverse effects
Disease Models, Animal
Epoprostenol
/ administration & dosage
Fatty Acids, Unsaturated
/ metabolism
Female
Humans
Inflammatory Bowel Diseases
/ chemically induced
Intestinal Mucosa
/ cytology
Male
Metabolomics
Mice
Mice, Inbred C57BL
Middle Aged
Permeability
/ drug effects
Tight Junction Proteins
/ genetics
Young Adult
Caspase-3
Human Mucosa
IBD
Lipidomic
Occludin
Omega-6 (n-6)
PGI(2)
Journal
Cellular and molecular gastroenterology and hepatology
ISSN: 2352-345X
Titre abrégé: Cell Mol Gastroenterol Hepatol
Pays: United States
ID NLM: 101648302
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
05
2020
revised:
01
05
2021
accepted:
03
05
2021
pubmed:
11
5
2021
medline:
12
3
2022
entrez:
10
5
2021
Statut:
ppublish
Résumé
Inflammatory bowel diseases (IBDs) that encompass both ulcerative colitis and Crohn's disease are a major public health problem with an etiology that has not been fully elucidated. There is a need to improve disease outcomes and preventive measures by developing new effective and lasting treatments. Although polyunsaturated fatty acid metabolites play an important role in the pathogenesis of several disorders, their contribution to IBD is yet to be understood. Polyunsaturated fatty acids metabolite profiles were established from biopsy samples obtained from Crohn's disease, ulcerative colitis, or control patients. The impact of a prostaglandin I A significant reduction of PGI The present study identified a PGI
Sections du résumé
BACKGROUND & AIMS
Inflammatory bowel diseases (IBDs) that encompass both ulcerative colitis and Crohn's disease are a major public health problem with an etiology that has not been fully elucidated. There is a need to improve disease outcomes and preventive measures by developing new effective and lasting treatments. Although polyunsaturated fatty acid metabolites play an important role in the pathogenesis of several disorders, their contribution to IBD is yet to be understood.
METHODS
Polyunsaturated fatty acids metabolite profiles were established from biopsy samples obtained from Crohn's disease, ulcerative colitis, or control patients. The impact of a prostaglandin I
RESULTS
A significant reduction of PGI
CONCLUSIONS
The present study identified a PGI
Identifiants
pubmed: 33971327
pii: S2352-345X(21)00090-4
doi: 10.1016/j.jcmgh.2021.05.001
pmc: PMC8342971
pii:
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Tight Junction Proteins
0
Dextran Sulfate
9042-14-2
Epoprostenol
DCR9Z582X0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1037-1060Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.