Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive rat.
Albuminuria
/ physiopathology
Animals
Blood Pressure
/ drug effects
Caseins
/ pharmacology
Dietary Fats
/ pharmacology
Dietary Proteins
/ metabolism
Edible Grain
/ chemistry
Female
Glutens
/ pharmacology
Hypertension
/ physiopathology
Kidney
/ physiopathology
Kidney Diseases
/ physiopathology
Nitric Oxide Synthase Type III
Pre-Eclampsia
/ physiopathology
Pregnancy
Rats
Rats, Inbred Dahl
Retinoic Acid 4-Hydroxylase
Dietary protein
Hypertension
Pregnancy
Renal damage
Journal
Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
02
02
2021
revised:
19
04
2021
accepted:
28
04
2021
pubmed:
11
5
2021
medline:
9
11
2021
entrez:
10
5
2021
Statut:
ppublish
Résumé
Preeclampsia (PE) is a disorder of pregnancy, which is categorized by hypertension and proteinuria or signs of end-organ damage. Though PE is the leading cause of maternal and fetal morbidity and mortality, the mechanisms leading to PE remain unclear. The present study examined the contribution of dietary protein source (casein versus wheat gluten) to the risk of developing maternal syndrome utilizing two colonies of Dahl salt-sensitive (SS/JrHsdMcwi) rats. While the only difference between the colonies is the diet, the colonies exhibit profound differences in the pregnancy phenotypes. The SS rats maintained on the wheat gluten (SSWG) chow are protected from developing maternal syndrome; however, approximately half of the SS rats fed a casein-based diet (SSC) exhibit maternal syndrome. Those SSC rats that develop pregnancy-specific increases in blood pressure and proteinuria have no observable differences in renal or placental immune profiles compared to the protected SS rats. A gene profile array of placental tissue revealed a downregulation in Nos3 and Cyp26a1 in the SSC rats that develop maternal syndrome accompanied with increases in uterine artery resistance index suggesting the source of this phenotype could be linked to inadequate remodeling within the placenta. Investigations into the effects of multiple pregnancies on maternal health replicated similar findings. The SSC colony displayed an exacerbation in proteinuria, renal hypertrophy and renal immune cell infiltration associated with an increased mortality rate while the SSWG colony were protected highlighting how dietary protein source could have beneficial effects in PE.
Identifiants
pubmed: 33971615
pii: S2210-7789(21)00031-3
doi: 10.1016/j.preghy.2021.04.002
pmc: PMC8182412
mid: NIHMS1702152
pii:
doi:
Substances chimiques
Caseins
0
Dietary Fats
0
Dietary Proteins
0
Glutens
8002-80-0
Nitric Oxide Synthase Type III
EC 1.14.13.39
Nos3 protein, rat
EC 1.14.13.39
Retinoic Acid 4-Hydroxylase
EC 1.14.14.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126-134Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL116264
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151587
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137748
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 18POST33990140
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL143832
Pays : United States
Informations de copyright
Copyright © 2021 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
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