Shocking HIV-1 with immunomodulatory latency reversing agents.
HIV
Immunomodulatory latency reversing agents
Molecular mechanisms
Shock-and-kill
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
15
04
2021
accepted:
19
04
2021
pubmed:
12
5
2021
medline:
5
4
2022
entrez:
11
5
2021
Statut:
ppublish
Résumé
The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase) and to induce subsequent elimination of the reactivated cells by immune responses or virus-induced cytopathic effects (the "kill" phase). Studies using immunomodulatory LRAs such as blockers of immune checkpoint molecules, toll-like receptor agonists, cytokines and CD8
Identifiants
pubmed: 33972164
pii: S1044-5323(21)00009-9
doi: 10.1016/j.smim.2021.101478
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101478Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.