Breathing-driven prefrontal oscillations regulate maintenance of conditioned-fear evoked freezing independently of initiation.
Action Potentials
/ physiology
Animals
Antithyroid Agents
/ administration & dosage
Electrophysiology
Fear
/ physiology
Interneurons
/ cytology
Male
Markov Chains
Methimazole
/ administration & dosage
Mice
Mice, Inbred C57BL
Models, Psychological
Olfactory Bulb
/ physiology
Optogenetics
Periodicity
Prefrontal Cortex
/ physiology
Pyramidal Cells
/ cytology
Respiration
/ drug effects
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 05 2021
10 05 2021
Historique:
received:
17
10
2019
accepted:
28
03
2021
entrez:
11
5
2021
pubmed:
12
5
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Brain-body interactions are thought to be essential in emotions but their physiological basis remains poorly understood. In mice, regular 4 Hz breathing appears during freezing after cue-fear conditioning. Here we show that the olfactory bulb (OB) transmits this rhythm to the dorsomedial prefrontal cortex (dmPFC) where it organizes neural activity. Reduction of the respiratory-related 4 Hz oscillation, via bulbectomy or optogenetic perturbation of the OB, reduces freezing. Behavioural modelling shows that this is due to a specific reduction in freezing maintenance without impacting its initiation, thus dissociating these two phenomena. dmPFC LFP and firing patterns support the region's specific function in freezing maintenance. In particular, population analysis reveals that network activity tracks 4 Hz power dynamics during freezing and reaches a stable state at 4 Hz peak that lasts until freezing termination. These results provide a potential mechanism and a functional role for bodily feedback in emotions and therefore shed light on the historical James-Cannon debate.
Identifiants
pubmed: 33972521
doi: 10.1038/s41467-021-22798-6
pii: 10.1038/s41467-021-22798-6
pmc: PMC8110519
doi:
Substances chimiques
Antithyroid Agents
0
Methimazole
554Z48XN5E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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