Novel antimicrobial anionic cecropins from the spruce budworm feature a poly-L-aspartic acid C-terminus.
Amino Acid Sequence
Animals
Anti-Bacterial Agents
/ chemistry
Antineoplastic Agents
/ chemistry
Apoptosis
/ drug effects
Binding Sites
Cecropins
/ chemistry
Escherichia coli
/ drug effects
Evolution, Molecular
Humans
Hydrophobic and Hydrophilic Interactions
Insect Proteins
/ chemistry
Molecular Dynamics Simulation
Moths
/ chemistry
Peptides
/ chemistry
Phylogeny
Protein Binding
Protein Conformation, alpha-Helical
Protein Interaction Domains and Motifs
Proto-Oncogene Proteins c-bcl-2
/ chemistry
Static Electricity
C-terminal poly-l-aspartic acid
Choristoneura fumiferana
ancient duplication
anionic cecropins
anticancer and antimicrobial peptides
apoptotic motif
Journal
Proteins
ISSN: 1097-0134
Titre abrégé: Proteins
Pays: United States
ID NLM: 8700181
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
28
04
2021
received:
16
07
2020
accepted:
06
05
2021
pubmed:
12
5
2021
medline:
5
2
2022
entrez:
11
5
2021
Statut:
ppublish
Résumé
Cecropins form a family of amphipathic α-helical cationic peptides with broad-spectrum antibacterial properties and potent anticancer activity. The emergence of bacteria and cancer cells showing resistance to cationic antimicrobial peptides (CAMPs) has fostered a search for new, more selective and more effective alternatives to CAMPs. With this goal in mind, we looked for cecropin homologs in the genome and transcriptome of the spruce budworm, Choristoneura fumiferana. Not only did we find paralogs of the conventional cationic cecropins (Cfcec
Substances chimiques
Anti-Bacterial Agents
0
Antineoplastic Agents
0
BCL2 protein, human
0
Cecropins
0
Insect Proteins
0
Peptides
0
Proto-Oncogene Proteins c-bcl-2
0
polyaspartate
26063-13-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1205-1215Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2021 Wiley Periodicals LLC.
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