Gastrointestinal involvement in a patient with familial Mediterranean fever mimicking Crohn's disease: a case report.
Crohn’s disease
Familial Mediterranean fever
Inflammatory bowel disease unclassified
MEFV
Journal
Clinical journal of gastroenterology
ISSN: 1865-7265
Titre abrégé: Clin J Gastroenterol
Pays: Japan
ID NLM: 101477246
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
12
03
2021
accepted:
23
04
2021
pubmed:
12
5
2021
medline:
27
7
2021
entrez:
11
5
2021
Statut:
ppublish
Résumé
Familial Mediterranean fever (FMF) in gastrointestinal involvement has been considered rare, but resent reports suggest that FMF causes enterocolitis which is similar endoscopic findings to inflammatory bowel disease. The clinical characteristics and endoscopic findings of FMF with enterocolitis remain unclear. Here, we report a case of an FMF patient who had enterocolitis with stricture of the terminal ileum whose endoscopic and clinical features mimicked Crohn's disease. A 23-year-old man who was diagnosed with FMF 10 years ago presented with abdominal pain and diarrhea. Colonoscopy showed terminal ileitis and aphthous colitis; however, these findings, including the histopathology, did not confirm Crohn's disease. Therefore, we diagnosed FMF with enterocolitis and administered anti-interleukin-1β monoclonal antibody (canakinumab). The patient's symptoms improved with treatment, but after 1 year, lower abdominal pain recurred. Colonoscopy revealed a stricture of the terminal ileum. Endoscopic balloon dilation relieved his symptoms. At present, he has been followed up without surgical treatment by endoscopic balloon dilation every 6 month. Clinicians should be aware that FMF accompanied with enterocolitis may resemble Crohn's disease.
Identifiants
pubmed: 33974187
doi: 10.1007/s12328-021-01426-2
pii: 10.1007/s12328-021-01426-2
pmc: PMC8298211
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1103-1107Subventions
Organisme : Japanese Society for the Promotion of Science (JSPS) KAKENHI
ID : JP20K16962
Organisme : Japan Society for the Promotion of Science
ID : JP18H02799
Organisme : Japan Agency for Medical Research and Development (JP)
ID : 20ek0410057h0002
Informations de copyright
© 2021. The Author(s).
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