Assessing the role of a tissue-based assay in the diagnostic algorithm of autoimmune encephalitis.
Autoantibodies
Autoimmune diseases
Encephalitis
Encephalopathy
Precision medicine
Test utilization
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 07 2021
15 07 2021
Historique:
received:
31
01
2021
revised:
11
04
2021
accepted:
28
04
2021
pubmed:
12
5
2021
medline:
8
9
2021
entrez:
11
5
2021
Statut:
ppublish
Résumé
Tissue-based assay (TBA) is a widely-used method to detect neural autoantibodies, but the diagnostic accuracy for autoimmune encephalitis (AE) has not yet been adequately measured. We retrospectively evaluated the sensitivity and specificity of an indirect immunofluorescence TBA (IIF-TBA) in 159 patients with suspected AE. Serum and cerebrospinal fluid (CSF) specimens were collected and tested from December 2012 to September 2020. In the paired sample analysis, serum testing showed higher sensitivity than CSF, while the latter had higher specificity. Based on these results, we clarify the advantages of using a TBA as the principal screening method for patients with suspected AE.
Identifiants
pubmed: 33975245
pii: S0165-5728(21)00128-4
doi: 10.1016/j.jneuroim.2021.577601
pii:
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577601Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.