Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing.
Aging
/ genetics
Animals
Asymmetric Cell Division
/ genetics
CD8-Positive T-Lymphocytes
/ cytology
Cell Proliferation
/ drug effects
Gene Expression Regulation
Immunity, Innate
Immunologic Memory
/ genetics
Interferon-gamma
/ genetics
Interleukin-1beta
/ genetics
Interleukin-2 Receptor beta Subunit
/ genetics
Lectins, C-Type
/ genetics
Lymphocyte Activation
Mice
NK Cell Lectin-Like Receptor Subfamily K
/ genetics
Receptors, CXCR3
/ genetics
Receptors, Immunologic
/ genetics
Receptors, Interleukin-7
/ genetics
Signal Transduction
Sirolimus
/ pharmacology
TOR Serine-Threonine Kinases
/ antagonists & inhibitors
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
received:
16
06
2020
accepted:
09
04
2021
entrez:
12
5
2021
pubmed:
13
5
2021
medline:
28
5
2021
Statut:
epublish
Résumé
Efficient immune responses rely on heterogeneity, which in CD8
Identifiants
pubmed: 33976157
doi: 10.1038/s41467-021-22954-y
pii: 10.1038/s41467-021-22954-y
pmc: PMC8113513
doi:
Substances chimiques
Cxcr3 protein, mouse
0
IL1B protein, mouse
0
Il2rb protein, mouse
0
Interleukin-1beta
0
Interleukin-2 Receptor beta Subunit
0
Klrg1 protein, mouse
0
Klrk1 protein, mouse
0
Lectins, C-Type
0
NK Cell Lectin-Like Receptor Subfamily K
0
Receptors, CXCR3
0
Receptors, Immunologic
0
Receptors, Interleukin-7
0
Interferon-gamma
82115-62-6
mTOR protein, mouse
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2715Subventions
Organisme : Wellcome Trust
ID : 103830/Z/14/Z
Pays : United Kingdom
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