Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice.
Animals
Body Temperature Regulation
/ physiology
Fear
/ physiology
Hypothermia
/ chemically induced
Male
Mice, Inbred C57BL
Mice, Knockout
Neurons
/ metabolism
Optogenetics
/ methods
Proto-Oncogene Proteins c-fos
/ metabolism
Solitary Nucleus
/ metabolism
Subthalamic Nucleus
/ metabolism
TRPA1 Cation Channel
/ genetics
Thiazoles
Vasodilation
/ physiology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
received:
03
06
2020
accepted:
17
03
2021
entrez:
12
5
2021
pubmed:
13
5
2021
medline:
2
6
2021
Statut:
epublish
Résumé
The neural mechanisms of fear-associated thermoregulation remain unclear. Innate fear odor 2-methyl-2-thiazoline (2MT) elicits rapid hypothermia and elevated tail temperature, indicative of vasodilation-induced heat dissipation, in wild-type mice, but not in mice lacking Trpa1-the chemosensor for 2MT. Here we report that Trpa1
Identifiants
pubmed: 33976193
doi: 10.1038/s41467-021-22914-6
pii: 10.1038/s41467-021-22914-6
pmc: PMC8113537
doi:
Substances chimiques
Proto-Oncogene Proteins c-fos
0
TRPA1 Cation Channel
0
Thiazoles
0
Trpa1 protein, mouse
0
2-methylthiazoline
8Z6UA8V7WN
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2648Commentaires et corrections
Type : ErratumIn
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