antisense
bioanalysis
isotope
oligonucleotide
phosphorothioate
quantification
Journal
Nucleic acid therapeutics
ISSN: 2159-3345
Titre abrégé: Nucleic Acid Ther
Pays: United States
ID NLM: 101562758
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
pubmed:
13
5
2021
medline:
14
1
2022
entrez:
12
5
2021
Statut:
ppublish
Résumé
Stable isotope labeling (SIL) of active pharmaceutical ingredients (API) is a well-established technique for the accurate quantification of small-molecule drugs. As the scope of active ingredients is expanding into areas of larger molecules, such as oligonucleotides (ONs), the development of new quantification techniques is critical. Herein, we describe the analysis of a
Identifiants
pubmed: 33978476
doi: 10.1089/nat.2020.0915
doi:
Substances chimiques
Oligonucleotides
0
PCSK9 protein, human
EC 3.4.21.-
Pcsk9 protein, mouse
EC 3.4.21.-
Proprotein Convertase 9
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM