Multiple Computational Approaches for Predicting Drug Interactions with Human Equilibrative Nucleoside Transporter 1.

Darunavir / pharmacokinetics Drug Interactions Equilibrative Nucleoside Transporter 1 / antagonists & inhibitors HeLa Cells Humans Nucleosides / analogs & derivatives Ribavirin / pharmacokinetics Ribonucleosides / pharmacokinetics Thioinosine / analogs & derivatives

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
07 2021
Historique:
received: 14 02 2021
accepted: 05 04 2021
pubmed: 14 5 2021
medline: 16 2 2022
entrez: 13 5 2021
Statut: ppublish

Résumé

Equilibrativenucleoside transporters (ENTs) participate in the pharmacokinetics and disposition of nucleoside analog drugs. Understanding drug interactions with the ENTs may inform and facilitate the development of new drugs, including chemotherapeutics and antivirals that require access to sanctuary sites such as the male genital tract. This study created three-dimensional pharmacophores for ENT1 and ENT2 substrates and inhibitors using K

Identifiants

DOI: 10.1124/dmd.121.000423 PMID: 33980604 PMC: PMC8313052
pubmed: 33980604
pii: dmd.121.000423
doi: 10.1124/dmd.121.000423
pmc: PMC8313052
doi:

Substances chimiques

Equilibrative Nucleoside Transporter 1 0
Nucleosides 0
Ribonucleosides 0
SLC29A1 protein, human 0
Thioinosine 46S541971T
Ribavirin 49717AWG6K
mizoribine 4JR41A10VP
4-nitrobenzylthioinosine GV1L2DZM2Z
Darunavir YO603Y8113

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

479-489

Subventions

Organisme : NIEHS NIH HHS
ID : T32 ES007091
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123643
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES006694
Pays : United States
Organisme : NIGMS NIH HHS
ID : R41 GM131433
Pays : United States
Organisme : NIGMS NIH HHS
ID : R44 GM122196
Pays : United States

Informations de copyright

Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics.

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Auteurs

Siennah R Miller (SR)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., N.J.C.), and College of Medicine, Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (T.R.L., K.M.Z., S.E.).

Thomas R Lane (TR)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., N.J.C.), and College of Medicine, Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (T.R.L., K.M.Z., S.E.).

Kimberley M Zorn (KM)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., N.J.C.), and College of Medicine, Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (T.R.L., K.M.Z., S.E.).

Sean Ekins (S)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., N.J.C.), and College of Medicine, Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (T.R.L., K.M.Z., S.E.).

Stephen H Wright (SH)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., N.J.C.), and College of Medicine, Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (T.R.L., K.M.Z., S.E.) cherring@pharmacy.arizona.edu shwright@email.arizona.edu.

Nathan J Cherrington (NJ)

College of Pharmacy, Department of Pharmacology & Toxicology (S.R.M., N.J.C.), and College of Medicine, Department of Physiology (S.H.W.), University of Arizona, Tucson, Arizona; and Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina (T.R.L., K.M.Z., S.E.) cherring@pharmacy.arizona.edu shwright@email.arizona.edu.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Furanes › Darunavir › Multiple Computational Approaches for...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Multiple Computational Approaches for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs équilibrants de nucléosides › Transporteur équilibrant de nucléosides de type 1 › Multiple Computational Approaches for...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Multiple Computational Approaches for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multiple Computational Approaches for...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Multiple Computational Approaches for...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Ribavirine › Multiple Computational Approaches for...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Multiple Computational Approaches for...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Thionucléosides › Thioinosine › Multiple Computational Approaches for...