Effects of chronic intermittent hypobaric hypoxia on prostate-specific antigen (PSA) in Chilean miners.
Adult
Altitude Sickness
/ complications
Chile
/ epidemiology
Cross-Sectional Studies
Hemoglobins
/ analysis
Humans
Male
Middle Aged
Miners
/ statistics & numerical data
Mining
/ statistics & numerical data
Occupational Diseases
/ epidemiology
Oxygen
/ blood
Prostate-Specific Antigen
/ blood
Young Adult
environment
miners
occupational health
public health surveillance
urology
Journal
Occupational and environmental medicine
ISSN: 1470-7926
Titre abrégé: Occup Environ Med
Pays: England
ID NLM: 9422759
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
19
11
2020
revised:
15
02
2021
accepted:
24
03
2021
pubmed:
14
5
2021
medline:
12
10
2021
entrez:
13
5
2021
Statut:
ppublish
Résumé
The aim was to determine the effects of chronic intermittent hypobaric hypoxia (CIHH) on prostate-specific antigen (PSA) levels in Chilean miners who work at different altitudes. A cross-sectional study was conducted between April and July 2019. Miners from five mines (N=338) at different altitudes were evaluated. We recorded sociodemographic, working and altitude information. Haemoglobin oxygen saturation (SaO Highest and lowest PSA levels were found in mines ≥3000 m above sea level (mine 3: median=0.75, IQR=-0.45; mine 4: median=0.46, IQR=-0.35). In the multilevel models, the wider altitude difference between mining operation and camp showed lower PSA levels (model D: βPSA=-0.93 ng/mL, β Occupational health regulations and high altitude medicine should consider these results as initial evidence on the inclusion of new descriptors for CIHH and the possible effect of this exposure on PSA levels in this male-dominated occupational sector.
Identifiants
pubmed: 33980699
pii: oemed-2020-107232
doi: 10.1136/oemed-2020-107232
pmc: PMC8448907
mid: NIHMS1698345
doi:
Substances chimiques
Hemoglobins
0
Prostate-Specific Antigen
EC 3.4.21.77
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
753-760Subventions
Organisme : FIC NIH HHS
ID : U2R TW010114
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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