Functional and diffusion MRI reveal the neurophysiological basis of neonates' noxious-stimulus evoked brain activity.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 05 2021
12 05 2021
Historique:
received:
13
04
2020
accepted:
05
04
2021
entrez:
13
5
2021
pubmed:
14
5
2021
medline:
29
5
2021
Statut:
epublish
Résumé
Understanding the neurophysiology underlying neonatal responses to noxious stimulation is central to improving early life pain management. In this neonatal multimodal MRI study, we use resting-state and diffusion MRI to investigate inter-individual variability in noxious-stimulus evoked brain activity. We observe that cerebral haemodynamic responses to experimental noxious stimulation can be predicted from separately acquired resting-state brain activity (n = 18). Applying this prediction model to independent Developing Human Connectome Project data (n = 215), we identify negative associations between predicted noxious-stimulus evoked responses and white matter mean diffusivity. These associations are subsequently confirmed in the original noxious stimulation paradigm dataset, validating the prediction model. Here, we observe that noxious-stimulus evoked brain activity in healthy neonates is coupled to resting-state activity and white matter microstructure, that neural features can be used to predict responses to noxious stimulation, and that the dHCP dataset could be utilised for future exploratory research of early life pain system neurophysiology.
Identifiants
pubmed: 33980860
doi: 10.1038/s41467-021-22960-0
pii: 10.1038/s41467-021-22960-0
pmc: PMC8115252
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2744Subventions
Organisme : Medical Research Council
ID : MR/L009013/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203139/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207457/Z/17/Z
Pays : United Kingdom
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