Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
12 05 2021
Historique:
received: 22 09 2020
accepted: 23 04 2021
entrez: 13 5 2021
pubmed: 14 5 2021
medline: 25 2 2023
Statut: epublish

Résumé

The diagnosis of mechanical asphyxia remains one of the most difficult issues in forensic pathology. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific markers, the differential diagnosis of primitive CA and CA secondary to asphyxiation relies on circumstantial details and on the pathologist experience, lacking objective evidence. Histological examination is currently considered the gold standard for CA post-mortem diagnosis. Here we present the comparative results of histopathology versus those previously obtained by

Identifiants

pubmed: 33980966
doi: 10.1038/s41598-021-89570-0
pii: 10.1038/s41598-021-89570-0
pmc: PMC8115104
doi:

Types de publication

Evaluation Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

10102

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Auteurs

Emanuela Locci (E)

Department of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy. elocci@unica.it.

Alberto Chighine (A)

Department of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.

Antonio Noto (A)

Department of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.

Giulio Ferino (G)

Department of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.

Alfonso Baldi (A)

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Caserta, Italy.

Dimitrios Varvarousis (D)

Cardiology Department, Asklepeion Hospital, Athens, Greece.

Theodoros Xanthos (T)

School of Medicine, European University Cyprus, Nicosia, Cyprus.

Fabio De-Giorgio (F)

Department of Health Care Surveillance and Bioethics, Section of Legal Medicine, Catholic University of Sacred Heart, Rome, Italy.
Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Matteo Stocchero (M)

Department of Women's and Children's Health, University of Padua, Padova, Italy.

Ernesto d'Aloja (E)

Department of Medical Sciences and Public Health, Section of Legal Medicine, University of Cagliari, Cagliari, Italy.

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