Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12.
A549 Cells
Animals
COVID-19
/ metabolism
Cell Line
Cell Line, Tumor
Chlorocebus aethiops
Cytokines
/ metabolism
Epithelial Cells
/ metabolism
Exosomes
/ metabolism
Humans
Interleukin-6
/ metabolism
Macrophages, Alveolar
/ metabolism
Male
Mice
Mice, Inbred C57BL
MicroRNAs
/ metabolism
NF-kappa B
/ metabolism
Plants
/ metabolism
Pneumonia
/ metabolism
SARS-CoV-2
/ pathogenicity
Tumor Necrosis Factor-alpha
/ metabolism
U937 Cells
Vero Cells
ACE2
IL-1β
IL-6
NF-κB
Nsp12
SARS-CoV-2
TNF-α
exosomes
ginger exosome-like nanoparticle
lung epithelial cells
lung inflammation
macrophages
microRNA
spike
Journal
Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581
Informations de publication
Date de publication:
04 08 2021
04 08 2021
Historique:
received:
03
12
2020
revised:
28
03
2021
accepted:
05
05
2021
pubmed:
14
5
2021
medline:
17
8
2021
entrez:
13
5
2021
Statut:
ppublish
Résumé
Lung inflammation is a hallmark of coronavirus disease 2019 (COVID-19). In this study, we show that mice develop inflamed lung tissue after being administered exosomes released from the lung epithelial cells exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp12 and Nsp13 (exosomes
Identifiants
pubmed: 33984520
pii: S1525-0016(21)00257-4
doi: 10.1016/j.ymthe.2021.05.005
pmc: PMC8110335
pii:
doi:
Substances chimiques
Cytokines
0
Interleukin-6
0
MicroRNAs
0
NF-kappa B
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2424-2440Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES030283
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113226
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA024337
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125504
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT008617
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103436
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA028435
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.