Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 05 2021
14 05 2021
Historique:
received:
19
11
2020
accepted:
16
03
2021
entrez:
15
5
2021
pubmed:
16
5
2021
medline:
30
10
2021
Statut:
epublish
Résumé
Dengue virus is a major and rapidly growing public health concern in tropic and subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue virus outbreak to date, covering several regions. However, little is known about the genetic diversity of dengue virus (DENV) in Senegal. Here we report complete viral genomes from 17 previously undetected DENV cases from the city of Thiès. In total we identified 19 cases of DENV in a cohort of 198 individuals with fever collected in October and November 2018. We detected 3 co-circulating serotypes; DENV 3 was the most frequent accounting for 11/17 sequences (65%), 4 (23%) were DENV2 and 2 (12%) were DENV1. Sequences were most similar to recent sequences from West Africa, suggesting ongoing local circulation of viral populations; however, detailed inference is limited by the scarcity of available genomic data. We did not find clear associations with reported clinical signs or symptoms, highlighting the importance of testing for diagnosing febrile diseases. Overall, these findings expand the known range of DENV in Senegal, and underscore the need for better genomic characterization of DENV in West Africa.
Identifiants
pubmed: 33990632
doi: 10.1038/s41598-021-89070-1
pii: 10.1038/s41598-021-89070-1
pmc: PMC8121849
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10321Subventions
Organisme : NIAID NIH HHS
ID : U01 AI151812
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG007480
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
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