Can breast cancer be stopped? Modifiable risk factors of breast cancer among women with a prior benign or premalignant lesion.
Adenocarcinoma in Situ
Alcohol Drinking
/ adverse effects
Body Mass Index
Breast Neoplasms
/ epidemiology
Cohort Studies
Disease Progression
Estrogen Replacement Therapy
/ adverse effects
Female
Humans
Middle Aged
Norway
Precancerous Conditions
/ epidemiology
Registries
Risk Assessment
Risk Factors
Sedentary Behavior
Surveys and Questionnaires
Tobacco Smoking
/ adverse effects
alcohol
body mass index
early detection of breast cancer
menopausal hormone therapy
physical activity
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
revised:
11
04
2021
received:
12
06
2020
accepted:
28
04
2021
pubmed:
16
5
2021
medline:
14
9
2021
entrez:
15
5
2021
Statut:
ppublish
Résumé
Physical inactivity, high postmenopausal body mass index, alcohol consumption and use of menopausal hormone therapy are established risk factors for breast cancer. Less is known about whether these factors influence the risk of progression of benign and premalignant breast lesions to invasive breast cancer. This registry-based cohort study was based on women with a precancerous lesion who were followed for breast cancer. The cohort consisted of 11 270 women with a benign lesion, 972 women with hyperplasia with atypia and 2379 women with carcinoma in situ diagnosed and treated after participation in BreastScreen Norway, 2006-2016. Information on breast cancer risk factors was collected by a questionnaire administered with the invitation letter. Cox regression analysis was used to estimate the association between breast cancer and physical activity, body mass index, alcohol consumption, tobacco smoking and menopausal hormone therapy, adjusted for age. During follow-up, 274 women with a benign lesion, 34 women with hyperplasia with atypia and 118 women with carcinoma in situ were diagnosed with invasive breast cancer. We observed an increased risk of breast cancer associated with use of menopausal hormone therapy for women with a benign or premalignant lesion. Alcohol consumption and tobacco smoking showed suggestive increased risk of breast cancer among women with a benign lesion. We were only to a limited degree able to identify associations between modifiable risk factors of breast cancer and the disease among women with a precancerous lesion, and a larger study is needed to confirm or refute associations.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1247-1256Informations de copyright
© 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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