Anti-trypanosomal and anthelminthic properties of ethanol and aqueous extracts of Tetrapleura tetraptera Taub.

Albendazole / chemistry Anthelmintics / chemistry Ethanol Fruit / chemistry Gas Chromatography-Mass Spectrometry / veterinary Oleic Acids / chemistry Pentacyclic Triterpenes / analysis Phytochemicals / chemistry Plant Bark / chemistry Plant Extracts / chemistry Plant Stems / chemistry Plants, Medicinal Tetrapleura / chemistry Trypanocidal Agents / chemistry Trypanosoma brucei brucei / drug effects Water Betulinic Acid
Anthelminthic Anti-trypanosomal Medicinal plants T. b brucei Tetrapleura tetraptera

Journal

Veterinary parasitology
ISSN: 1873-2550
Titre abrégé: Vet Parasitol
Pays: Netherlands
ID NLM: 7602745

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 25 11 2020
revised: 05 05 2021
accepted: 06 05 2021
pubmed: 16 5 2021
medline: 21 8 2021
entrez: 15 5 2021
Statut: ppublish

Résumé

Trypanosomosis and helminthosis, considered as part of neglected tropical diseases, are parasitic infections of public health importance, especially in Africa. Medicinal plants have been used in most parts of Africa, to treat these parasitic infections. The study aims to determine the anti-trypanosomal and anthelminthic properties of Tetrapleura tetraptera (fruit and stembark). The aqueous extracts of T. tetraptera fruit (TTFaq) and stembark (TTSaq), as well as ethanol extracts of T. tetraptera fruit (TTFe) and stembark (TTSe), were screened for their in vitro anti-trypanosomal and anthelminthic activities against T. b. brucei and Pheretima posthuma worms, respectively. Preliminary phytochemical screening of all extracts and gas chromatography-mass spectrometry (GC-MS) analysis of most active extracts were conducted. TTFaq exhibited anti-trypanosomal activity with IC

Identifiants

DOI: 10.1016/j.vetpar.2021.109449 PMID: 33991727
pubmed: 33991727
pii: S0304-4017(21)00109-6
doi: 10.1016/j.vetpar.2021.109449
pii:
doi:

Substances chimiques

Anthelmintics 0
Oleic Acids 0
Pentacyclic Triterpenes 0
Phytochemicals 0
Plant Extracts 0
Trypanocidal Agents 0
Water 059QF0KO0R
Ethanol 3K9958V90M
oleylamide 7L25QK8BWO
Albendazole F4216019LN
Betulinic Acid 4G6A18707N

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109449

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Ahmed Wahab Obeng (A)

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Yaw Duah Boakye (YD)

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address: ydboakye.pharm@knust.edu.gh.

Theresa Appiah Agana (TA)

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Georgina Isabella Djameh (GI)

Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, P.O. Box LG 581, Legon, Ghana.

Daniel Boamah (D)

Department of Microbiology, Mampong Centre for Plant Medicine Research, Akuapem Mampong, Ghana.

Francis Adu (F)

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Albendazole › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Anthelminthiques › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Aliments et boissons › Aliments › Fruit › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Chromatographie gazeuse-spectrométrie de masse › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Acides oléiques › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Triterpènes pentacycliques › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Épiderme végétal › Écorce › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Tiges de plante › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Eucaryotes › Plantes › Plantes médicinales › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Tetrapleura › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma brucei brucei › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Anti-trypanosomal and anthelminthic properties...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Triterpènes pentacycliques › Lupanes › Acide bétulinique › Anti-trypanosomal and anthelminthic properties...