The Inside-Out of End-Stage Liver Disease: Hepatocytes are the Keystone.
Journal
Seminars in liver disease
ISSN: 1098-8971
Titre abrégé: Semin Liver Dis
Pays: United States
ID NLM: 8110297
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
pubmed:
16
5
2021
medline:
26
11
2021
entrez:
15
5
2021
Statut:
ppublish
Résumé
Chronic liver injury results in cirrhosis and end-stage liver disease (ESLD) which represents a leading cause of death worldwide, affecting people in their most productive years of life. Medical therapy can extend life, but the only definitive treatment is liver transplantation (LT). However, LT remains limited by access to quality donor organs and suboptimal long-term outcomes. The degeneration from healthy-functioning livers to cirrhosis and ESLD involves a dynamic process of hepatocyte damage, diminished hepatic function, and adaptation. However, the mechanisms responsible for deterioration of hepatocyte function and ultimately hepatic failure in man are poorly understood. We review the current understanding of cirrhosis and ESLD as a dynamic process and outline the current mechanisms associated with the development of hepatic failure from the clinical manifestations to energy adaptations, regeneration, and regulation of nuclear transcription factors. A new generation of therapeutics could target stabilization of hepatocyte differentiation and function to avoid the need for transplantation in patients with cirrhosis and ESLD.
Identifiants
pubmed: 33992030
doi: 10.1055/s-0041-1725023
pmc: PMC8996333
mid: NIHMS1791187
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
213-224Subventions
Organisme : NCATS NIH HHS
ID : U01 TR002383
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK119973
Pays : United States
Organisme : NIDDK NIH HHS
ID : P01 DK096990
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099257
Pays : United States
Organisme : NIDDK NIH HHS
ID : UG3 DK119973
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117881
Pays : United States
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
None declared.
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