The association of genetically determined serum glycine with cardiovascular risk in East Asians.
Asian People
/ genetics
Biomarkers
/ blood
Carbamoyl-Phosphate Synthase (Ammonia)
/ genetics
Case-Control Studies
China
/ ethnology
Coronary Angiography
Coronary Artery Disease
/ blood
Genetic Predisposition to Disease
Genome-Wide Association Study
Glycine
/ blood
Heart Disease Risk Factors
Humans
Incidence
Polymorphism, Single Nucleotide
Prognosis
Prospective Studies
Risk Assessment
Singapore
/ epidemiology
Cardiovascular risk
Circulating glycine concentration
Genetic association
Genome-wide association study
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
ISSN: 1590-3729
Titre abrégé: Nutr Metab Cardiovasc Dis
Pays: Netherlands
ID NLM: 9111474
Informations de publication
Date de publication:
07 06 2021
07 06 2021
Historique:
received:
02
09
2020
revised:
26
02
2021
accepted:
04
03
2021
pubmed:
17
5
2021
medline:
29
6
2021
entrez:
16
5
2021
Statut:
ppublish
Résumé
Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138). Our study, a first in East Asians, suggest a protective role of glycine against CAD.
Sections du résumé
BACKGROUND AND AIMS
Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians.
METHODS AND RESULTS
We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138).
CONCLUSION
Our study, a first in East Asians, suggest a protective role of glycine against CAD.
Identifiants
pubmed: 33992511
pii: S0939-4753(21)00127-7
doi: 10.1016/j.numecd.2021.03.010
pmc: PMC10442847
mid: NIHMS1916764
pii:
doi:
Substances chimiques
Biomarkers
0
CPS1 protein, human
EC 6.3.4.16
Carbamoyl-Phosphate Synthase (Ammonia)
EC 6.3.4.16
Glycine
TE7660XO1C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1840-1844Subventions
Organisme : NCI NIH HHS
ID : R01 CA080205
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA144034
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA182876
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182876
Pays : United States
Informations de copyright
Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.
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