Biphalin, a dimeric opioid peptide, reduces neonatal hypoxia-ischemia brain injury in mice by the activation of PI3K/Akt signaling pathway.
Animals
Brain
/ drug effects
Disease Models, Animal
Enkephalins
/ pharmacology
Hypoxia-Ischemia, Brain
/ drug therapy
Mice
Narcotic Antagonists
/ pharmacology
Neuroprotective Agents
/ pharmacology
Phosphatidylinositol 3-Kinases
/ metabolism
Phosphorylation
/ drug effects
Polyethylene Terephthalates
/ pharmacology
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
/ drug effects
Akt
Biphalin
Hypoxia-ischemia
Neonatal
Opioid receptor
Journal
Journal of chemical neuroanatomy
ISSN: 1873-6300
Titre abrégé: J Chem Neuroanat
Pays: Netherlands
ID NLM: 8902615
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
12
03
2021
revised:
10
05
2021
accepted:
11
05
2021
pubmed:
17
5
2021
medline:
19
2
2022
entrez:
16
5
2021
Statut:
ppublish
Résumé
Previous studies have demonstrated that the activation of delta opioid receptors is neuroprotective against neonatal hypoxia-ischemia (HI) brain injury. The aim of this study was to investigate the neuroprotective effects of biphalin, a dimeric opioid peptide, in a mouse model of neonatal HI and the underlying mechanisms. On postnatal day 10, mouse pups were subjected to unilateral carotid artery ligation followed by 1 h of hypoxia (10 % O
Identifiants
pubmed: 33992725
pii: S0891-0618(21)00050-8
doi: 10.1016/j.jchemneu.2021.101967
pii:
doi:
Substances chimiques
Enkephalins
0
Narcotic Antagonists
0
Neuroprotective Agents
0
Polyethylene Terephthalates
0
biphalin
83916-01-2
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101967Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.