Rescue immunoadsorption treatment for neuromyelitis optica spectrum disorder attacks unresponsive to intravenous methylprednisolone.
Aquaporin 4
Immunoadsorption
Methylprednisolone
Myelitis
Neuromyelitis optica
Plasmapheresis
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 07 2021
15 07 2021
Historique:
received:
08
04
2021
revised:
29
04
2021
accepted:
05
05
2021
pubmed:
17
5
2021
medline:
8
9
2021
entrez:
16
5
2021
Statut:
ppublish
Résumé
We aimed to evaluate the value of immunoadsorption (IA) treatment after the failure of intravenous methylprednisolone (IVMP) therapy for neuromyelitis optica spectrum disorder (NMOSD). Sixty-one NMOSD attacks unresponsive to IVMP were included: 22 patients received rescue IA (IVMP+IA), 24 underwent rescue plasma exchange (PE) (IVMP+PE), and 21 received no further rescue therapy (IVMP alone). The improvement frequencies were higher in the IVMP+IA and IVMP+PE groups than in the IVMP-alone group (P = 0.024). The effective period for IA treatment may be longer than previously thought. IA treatment for IVMP-resistant NMOSD attacks was effective and comparable to PE treatment.
Identifiants
pubmed: 33992860
pii: S0165-5728(21)00131-4
doi: 10.1016/j.jneuroim.2021.577604
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Methylprednisolone
X4W7ZR7023
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577604Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.