AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner.
Metabolite
metabolite sensing
methionine cycle
methyltransferase
one-carbon metabolism
signaling molecule
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
pubmed:
18
5
2021
medline:
27
4
2022
entrez:
17
5
2021
Statut:
ppublish
Résumé
S-adenosyl-l-homocysteine (SAH), an amino acid derivative, is a key intermediate metabolite in methionine metabolism, which is normally considered as a harmful by-product and hydrolyzed quickly once formed. AHCY (adenosylhomocysteinase) converts SAH into homocysteine and adenosine. There are two other members in the AHCY family, AHCYL1 (adenosylhomocysteinase like 1) and AHCYL2 (adenosylhomocysteinase like 2). Here we define AHCYL1 function as a SAH sensor to inhibit macroautophagy/autophagy through PIK3C3. The C terminus of AHCYL1 interacts with SAH specifically and the interaction with SAH promotes the binding of the N terminus to the catalytic domain of PIK3C3, resulting in inhibition of PIK3C3. More importantly, this observation was further validated
Identifiants
pubmed: 33993848
doi: 10.1080/15548627.2021.1924038
pmc: PMC8942424
doi:
Substances chimiques
S-Adenosylhomocysteine
979-92-0
Class III Phosphatidylinositol 3-Kinases
EC 2.7.1.137
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Adenosylhomocysteinase
EC 3.3.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
309-319Références
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