NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells.
Animals
Cells, Cultured
Cytokines
/ biosynthesis
Cytotoxicity, Immunologic
/ genetics
Granzymes
/ metabolism
Humans
Killer Cells, Natural
/ immunology
Melanoma, Experimental
Mice
Mice, Knockout
Models, Biological
NF-kappa B
/ metabolism
Pore Forming Cytotoxic Proteins
/ genetics
Proto-Oncogene Proteins c-rel
/ genetics
NF-κB c-Rel
NK cell
cytotoxicity
granzyme
perforin (Prf1)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
01
2021
accepted:
12
04
2021
entrez:
17
5
2021
pubmed:
18
5
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both
Identifiants
pubmed: 33995369
doi: 10.3389/fimmu.2021.652786
pmc: PMC8116710
doi:
Substances chimiques
Cytokines
0
NF-kappa B
0
Pore Forming Cytotoxic Proteins
0
Proto-Oncogene Proteins c-rel
0
Granzymes
EC 3.4.21.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
652786Subventions
Organisme : NCATS NIH HHS
ID : TL1 TR002549
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI144264
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA043703
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA232648
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007250
Pays : United States
Informations de copyright
Copyright © 2021 Vicioso, Wong, Roy, Das, Zhang, Ramakrishnan and Parameswaran.
Déclaration de conflit d'intérêts
RP is a consultant for Luminary therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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