Sex, HIV Status, and Measures of Cardiac Stress and Fibrosis in Uganda.
Comorbidity
Echocardiography
/ methods
Female
Fibrosis
/ diagnosis
Follow-Up Studies
HIV
HIV Infections
/ diagnosis
Heart Diseases
/ diagnosis
Humans
Incidence
Male
Middle Aged
Retrospective Studies
Sex Distribution
Sex Factors
Stress, Physiological
Uganda
/ epidemiology
Ventricular Function, Left
/ physiology
HIV
cardiac biomarkers
cardiac fibrosis
echocardiography
sex
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
pubmed:
18
5
2021
medline:
29
10
2021
entrez:
17
5
2021
Statut:
ppublish
Résumé
Background Biomarkers of myocardial stress and fibrosis are elevated in people living with HIV and are associated with cardiac dysfunction. It is unknown whether sex influences these markers of heart failure risk in sub-Saharan Africa, where HIV burden is high and where the vast majority of women with HIV live. Methods and Results Echocardiograms and 6 plasma biomarkers (suppression of tumorigenicity-2, growth differentiation factor 15, galectin 3, soluble fms-like tyrosine kinase-1, NT-proBNP [N-terminal pro-B-type natriuretic peptide], and cystatin C) were obtained from 100 people living with HIV on antiretroviral therapy and 100 HIV-negative controls in Uganda. All participants were ≥45 years old with ≥1 major cardiovascular risk factor. Multivariable linear and logistic regression models were used to assess associations between biomarkers, echocardiographic variables, HIV status, and sex, and to assess whether sex modified these associations. Overall, mean age was 56 years and 62% were women. Suppression of tumorigenicity-2 was higher in men versus women (
Identifiants
pubmed: 33998251
doi: 10.1161/JAHA.120.018767
pmc: PMC8483535
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e018767Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL123341
Pays : United States
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