Long-term programming of skeletal muscle and liver lipid and energy metabolism by resveratrol supplementation to suckling mice.
Adenylate Kinase
/ genetics
Animals
Animals, Suckling
Antioxidants
/ pharmacology
Diet, High-Fat
Dietary Supplements
Energy Metabolism
/ drug effects
Female
Gene Expression Regulation
/ drug effects
Lipid Metabolism
/ drug effects
Liver
/ drug effects
Male
Maternal Nutritional Physiological Phenomena
Mice
Muscle, Skeletal
/ drug effects
RNA, Messenger
/ genetics
Resveratrol
/ pharmacology
Sirtuin 1
/ genetics
Dietary obesity
Early life nutrition
Metabolic programming
Oxidative metabolism
Polyphenols
Resveratrol
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
10
08
2020
revised:
04
03
2021
accepted:
29
04
2021
pubmed:
18
5
2021
medline:
18
9
2021
entrez:
17
5
2021
Statut:
ppublish
Résumé
Metabolic programming by dietary chemicals consumed in early life stages is receiving increasing attention. We here studied long-term effects of mild resveratrol (RSV) supplementation during lactation on muscular and hepatic lipid metabolism in adulthood. Newborn male mice received RSV or vehicle from day 2-20 of age, were weaned onto a chow diet on day 21, and were assigned to either a high-fat diet (HFD) or a normal-fat diet on day 90 of age for 10 weeks. RSV-treated mice showed in adulthood protection against HFD-induced triacylglycerol accumulation in skeletal muscle, enhanced muscular capacities for fat oxidation and mitochondria activity, signs of enhanced sirtuin 1 and AMP-dependent protein kinase signaling in muscle, and increased fat oxidation capacities and a decreased capacity for lipogenesis in liver compared with controls. Thus, RSV supplementation in early postnatal life may help preventing later diet-related disorders linked to ectopic lipid accumulation in muscle and liver tissues.
Identifiants
pubmed: 34000411
pii: S0955-2863(21)00190-X
doi: 10.1016/j.jnutbio.2021.108770
pii:
doi:
Substances chimiques
Antioxidants
0
RNA, Messenger
0
Adenylate Kinase
EC 2.7.4.3
Sirt1 protein, mouse
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Resveratrol
Q369O8926L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108770Informations de copyright
Copyright © 2021. Published by Elsevier Inc.