Diffusion-weighted and dynamic contrast-enhanced MRI to assess radiation therapy response for head and neck paragangliomas.
DCE-MRI
DWI
head and neck
paraganglioma
radiation therapy
Journal
Journal of neuroimaging : official journal of the American Society of Neuroimaging
ISSN: 1552-6569
Titre abrégé: J Neuroimaging
Pays: United States
ID NLM: 9102705
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
11
04
2021
received:
31
03
2021
accepted:
26
04
2021
pubmed:
19
5
2021
medline:
27
10
2021
entrez:
18
5
2021
Statut:
ppublish
Résumé
The prediction of radiotherapy outcome in head and neck paragangliomas is clinically important. We investigated perfusion and diffusion markers for evaluation of response to radiotherapy of head and neck paragangliomas. We retrospectively reviewed 330 consecutive patients from January 2016 to September 2019 with suspected head and neck paragangliomas, and enrolled 11 patients (2 males, 9 females; age: 55.2 ± 10.3 years) who had conventional MRI and dynamic contrast-enhanced (DCE)-MRI before and after radiation therapy. Radiation therapy, consisting of external beam radiotherapy or stereotactic radiotherapy, was conducted at the radiation oncology department in a single center. Mean apparent diffusion coefficient (ADC), normalized mean ADC, and parameters of DCE-MRI were compared between pre- and post-treatment status by paired t-test. The Pearson correlation coefficient was used for the relationship between tumor volume ratio (post-treatment status/pre-treatment status) and pre-treatment and post-treatment values. Mean and normalized ADC values were statistically higher in post-treatment status than pre-treatment status (p = 0.005, p = 0.005, respectively), and Ktrans (volume transfer constant between extravascular, extracellular space [EES], and blood plasma per minute) and Kep (rate transfer constant between EES and blood plasma per minute) were significantly lower in post-treatment status than pre-treatment status (p = 0.007, p = 0.027, respectively). The correlation coefficient of the relationship between tumor volume ratio and pre-treatment Ktrans (r = 0.70; p = 0.016) and between tumor volume ratio and post-treatment Ktrans and Kep (r = 0.83; p = 0.002, r = 0.8; p = 0.003, respectively) was statistically significant. Ktrans has predictive potential to predict the response to radiation therapy of head and neck paragangliomas.
Sections du résumé
BACKGROUND AND PURPOSE
The prediction of radiotherapy outcome in head and neck paragangliomas is clinically important. We investigated perfusion and diffusion markers for evaluation of response to radiotherapy of head and neck paragangliomas.
METHODS
We retrospectively reviewed 330 consecutive patients from January 2016 to September 2019 with suspected head and neck paragangliomas, and enrolled 11 patients (2 males, 9 females; age: 55.2 ± 10.3 years) who had conventional MRI and dynamic contrast-enhanced (DCE)-MRI before and after radiation therapy. Radiation therapy, consisting of external beam radiotherapy or stereotactic radiotherapy, was conducted at the radiation oncology department in a single center. Mean apparent diffusion coefficient (ADC), normalized mean ADC, and parameters of DCE-MRI were compared between pre- and post-treatment status by paired t-test. The Pearson correlation coefficient was used for the relationship between tumor volume ratio (post-treatment status/pre-treatment status) and pre-treatment and post-treatment values.
RESULTS
Mean and normalized ADC values were statistically higher in post-treatment status than pre-treatment status (p = 0.005, p = 0.005, respectively), and Ktrans (volume transfer constant between extravascular, extracellular space [EES], and blood plasma per minute) and Kep (rate transfer constant between EES and blood plasma per minute) were significantly lower in post-treatment status than pre-treatment status (p = 0.007, p = 0.027, respectively). The correlation coefficient of the relationship between tumor volume ratio and pre-treatment Ktrans (r = 0.70; p = 0.016) and between tumor volume ratio and post-treatment Ktrans and Kep (r = 0.83; p = 0.002, r = 0.8; p = 0.003, respectively) was statistically significant.
CONCLUSIONS
Ktrans has predictive potential to predict the response to radiation therapy of head and neck paragangliomas.
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1035-1043Informations de copyright
© 2021 American Society of Neuroimaging.
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