Spinal cord fMRI with MB-SWIFT for assessing epidural spinal cord stimulation in rats.
MB-SWIFT
epidural stimulation
fMRI
rats
spinal cord stimulation
zero echo time
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
01
04
2021
received:
11
01
2021
accepted:
26
04
2021
pubmed:
19
5
2021
medline:
3
8
2021
entrez:
18
5
2021
Statut:
ppublish
Résumé
Electrical epidural spinal cord stimulation (SCS) is used as a treatment for chronic pain as well as to partially restore motor function after a spinal cord injury. Monitoring the spinal cord activity during SCS with fMRI could provide important and objective measures of integrative responses to treatment. Unfortunately, spinal cord fMRI is severely challenged by motion and susceptibility artifacts induced by the implanted electrode and bones. This pilot study introduces multi-band sweep imaging with Fourier transformation (MB-SWIFT) technique for spinal cord fMRI during SCS in rats. Given the close to zero acquisition delay and high bandwidth in 3 dimensions, MB-SWIFT is demonstrated to be highly tolerant to motion and susceptibility-induced artifacts and thus holds promise for fMRI during SCS. MB-SWIFT with 0.78 × 0.78 × 1.50 mm MB-SWIFT was tolerant to electrode-induced artifacts and respiratory motion, leading to substantially higher fMRI sensitivity than spin echo fMRI. Clear stimulation frequency-dependent responses to SCS were detected in the rat spinal cord close to the stimulation site. The origin of MB-SWIFT fMRI signals was consistent with dominant inflow effects. fMRI of the rat spinal cord during SCS can be consistently achieved with MB-SWIFT, thus providing a valuable experimental framework for assessing the effects of SCS on the central nervous system.
Identifiants
pubmed: 34002880
doi: 10.1002/mrm.28844
pmc: PMC8360072
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2137-2145Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB027061
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015894
Pays : United States
Organisme : NIH HHS
ID : U01 NS103569
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025031
Pays : United States
Organisme : NIH HHS
ID : P41 EB015894
Pays : United States
Organisme : NIH HHS
ID : S10 RR025031
Pays : United States
Organisme : The Emil Aaltonen Foundation
Organisme : NINDS NIH HHS
ID : U01 NS103569
Pays : United States
Organisme : Academy of Finland
ID : 331955
Informations de copyright
© 2021 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
Références
Neuroimage. 2017 Oct 1;159:443-448
pubmed: 28797739
Curr Pain Headache Rep. 2014 Apr;18(4):406
pubmed: 24595705
Neuroimage. 2017 Jul 1;154:255-266
pubmed: 27693613
Nature. 2018 Nov;563(7729):65-71
pubmed: 30382197
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9868-72
pubmed: 2124706
Neurotherapeutics. 2014 Jul;11(3):543-52
pubmed: 25015323
Neuroimage. 1996 Dec;4(3 Pt 1):174-82
pubmed: 9345507
Nat Med. 2018 Nov;24(11):1677-1682
pubmed: 30250140
Pain Physician. 2014 May-Jun;17(3):235-46
pubmed: 24850105
IEEE Trans Image Process. 2009 Nov;18(11):2419-34
pubmed: 19635705
Proc Natl Acad Sci U S A. 1997 May 13;94(10):5034-9
pubmed: 9144185
Curr Pain Headache Rep. 2019 May 1;23(6):39
pubmed: 31044337
Neuron. 2014 Nov 19;84(4):716-722
pubmed: 25447740
J Magn Reson Imaging. 2014 Oct;40(4):770-7
pubmed: 24925698
Neuroimage. 2017 Feb 15;147:10-18
pubmed: 27876655
Brain Res. 2014 Jun 20;1569:19-31
pubmed: 24802658
Neuroimage. 2014 Jan 1;84:1070-81
pubmed: 23685159
J Magn Reson. 2015 Feb;251:19-25
pubmed: 25557859
Neuromodulation. 2016 Feb;19(2):142-53
pubmed: 26373920
Neuroimage. 2014 Jan 1;84:1082-93
pubmed: 23859923
Magn Reson Med. 2002 Jul;48(1):122-7
pubmed: 12111939
Neurosurg Rev. 2016 Jan;39(1):27-35; discussion 35
pubmed: 26219854
Eur Spine J. 2017 Jan;26(1):71-77
pubmed: 27311305
Bioelectron Med. 2019 Jun 28;5:
pubmed: 31435499
J Magn Reson Imaging. 2015 Apr;41(4):1046-55
pubmed: 24737401
Nat Commun. 2018 Aug 1;9(1):3015
pubmed: 30068906
Magn Reson Imaging. 2014 Jun;32(5):473-81
pubmed: 24602827
Science. 2009 Mar 20;323(5921):1578-82
pubmed: 19299613
Eur J Pain. 2008 Feb;12(2):137-48
pubmed: 17977762
Front Neurol. 2019 Mar 18;10:222
pubmed: 30936849
Neurosurgery. 1997 Aug;41(2):501-4
pubmed: 9257323
Magn Reson Med. 2021 Oct;86(4):2137-2145
pubmed: 34002880
Magn Reson Med. 2007 Jul;58(1):185-9
pubmed: 17659610
Neuroimage. 2020 Feb 1;206:116338
pubmed: 31730923
Science. 1965 Nov 19;150(3699):971-9
pubmed: 5320816