Open-source image analysis software yields reproducible MRI measures of lumbar intervertebral disc degeneration in sheep models.
imaging
lower back pain
ovine
spine
translational research
Journal
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
ISSN: 1740-8261
Titre abrégé: Vet Radiol Ultrasound
Pays: England
ID NLM: 9209635
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
18
03
2021
received:
11
01
2021
accepted:
21
03
2021
pubmed:
19
5
2021
medline:
26
11
2021
entrez:
18
5
2021
Statut:
ppublish
Résumé
Sheep are established models for intervertebral disc degeneration (IVDD) translational research. Objectives of this retrospective, secondary analysis, observational study were to evaluate reproducibility of two magnetic resonance imaging (MRI) measures of IVDD in sheep using open-source image analysis software. Sagittal planar, T2-weighted, lumbar MRI scans from a previous, prospective study were evaluated (4 sheep @ 3 treatment periods/sheep @ 7 lumbar discs /treatment period = 84 discs). A standardized protocol was developed for measuring MRI index (nucleus pulposus signal intensity × nucleus pulposus sagittal area), and nucleus pulposus signal intensity standard deviation (NPSISD). Scans were randomized and four observers with varying experience levels applied the protocol to independently perform triplicate measures. Mean coefficient of variation values for both the MRI index and NPSISD were within an acceptable range (< 10). Mean values for the three readers with at least 2 months of image analysis experience did not differ (P > .05).
Identifiants
pubmed: 34002920
doi: 10.1111/vru.12977
pmc: PMC9165648
mid: NIHMS1726226
doi:
Types de publication
Journal Article
Observational Study, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
568-572Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM121342
Pays : United States
Informations de copyright
© 2021 American College of Veterinary Radiology.
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