Serum ACE activity and plasma ACE concentration in patients with SARS-CoV-2 infection.

Adult Angiotensin-Converting Enzyme Inhibitors COVID-19 Humans Peptidyl-Dipeptidase A Prospective Studies SARS-CoV-2
ACE COVID-19 angiotensin renin-angiotensin-aldosterone system

Journal

Scandinavian journal of clinical and laboratory investigation
ISSN: 1502-7686
Titre abrégé: Scand J Clin Lab Invest
Pays: England
ID NLM: 0404375

Informations de publication

Date de publication:
07 2021
Historique:
pubmed: 19 5 2021
medline: 13 7 2021
entrez: 18 5 2021
Statut: ppublish

Résumé

Significant controversy has arisen over the role of the renin-angiotensin-aldosterone system (RAAS) in COVID-19 pathophysiology. In this prospective, observational study, we evaluated plasma angiotensin converting enzyme (ACE) concentration and serum ACE activity in 52 adults with laboratory-confirmed SARS-CoV-2 infection and 27 non-COVID-19 sick controls. No significant differences were observed in ACE activity in COVID-19 patients versus non-COVID-19 sick controls (41.1 [interquartile range (IQR): 23.0-55.2] vs. 42.9 [IQR 13.6-74.2] U/L,

Identifiants

DOI: 10.1080/00365513.2021.1926536 PMID: 34003706 PMC: PMC8146290
pubmed: 34003706
doi: 10.1080/00365513.2021.1926536
pmc: PMC8146290
doi:

Substances chimiques

Angiotensin-Converting Enzyme Inhibitors 0
Peptidyl-Dipeptidase A EC 3.4.15.1

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

272-275

Subventions

Organisme : NIDDK NIH HHS
ID : P50 DK096418
Pays : United States

Commentaires et corrections

Type : CommentOn

Auteurs

Brandon Michael Henry (BM)

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
ORCID: 0000-0002-8047-338X

Justin L Benoit (JL)

Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA.
ORCID: 0000-0002-0669-2963

James Rose (J)

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, OH, USA.

Maria Helena Santos de Oliveira (MHS)

Department of Statistics, Federal University of Parana, Curitiba, Brazil.

Giuseppe Lippi (G)

Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.
ORCID: 0000-0001-9523-9054

Stefanie W Benoit (SW)

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, OH, USA.
Department of Pediatrics, University of Cincinnati, College of Medicine, OH, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Serum ACE activity and plasma ACE...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Inhibiteurs de l'enzyme de conversion de l'angiotensine › Serum ACE activity and plasma ACE...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Serum ACE activity and plasma ACE...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Serum ACE activity and plasma ACE...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Dipeptidyl-Peptidases and Tripeptidyl-Peptidases › Peptidyl-Dipeptidase A › Serum ACE activity and plasma ACE...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Serum ACE activity and plasma ACE...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Serum ACE activity and plasma ACE...