Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis.

Animals Cell Differentiation / genetics Cell Lineage / genetics Chromatin / genetics Dendritic Cells / physiology Enhancer Elements, Genetic / genetics Female Hematopoiesis / genetics Humans Male Mice Mice, Inbred C57BL Monocytes / physiology Transcription, Genetic / genetics Zinc Finger E-box Binding Homeobox 2 / genetics
Zeb2 chromatin structure enhancer hematopoiesis transcriptional regulation zinc finger E-box binding homeobox 2

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
13 07 2021
Historique:
received: 18 01 2021
revised: 02 03 2021
accepted: 14 04 2021
pubmed: 19 5 2021
medline: 15 9 2021
entrez: 18 5 2021
Statut: ppublish

Résumé

The transcriptional repressor ZEB2 regulates development of many cell fates among somatic, neural, and hematopoietic lineages, but the basis for its requirement in these diverse lineages is unclear. Here, we identified a 400-basepair (bp) region located 165 kilobases (kb) upstream of the Zeb2 transcriptional start site (TSS) that binds the E proteins at several E-box motifs and was active in hematopoietic lineages. Germline deletion of this 400-bp region (Zeb2

Identifiants

DOI: 10.1016/j.immuni.2021.04.015 PMID: 34004142 PMC: PMC8282756
pubmed: 34004142
pii: S1074-7613(21)00177-1
doi: 10.1016/j.immuni.2021.04.015
pmc: PMC8282756
mid: NIHMS1697385
pii:
doi:

Substances chimiques

Chromatin 0
ZEB2 protein, mouse 0
Zinc Finger E-box Binding Homeobox 2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1417-1432.e7

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI150297
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI076427
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007200
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA230188
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA091842
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000448
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130152
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA260852
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests A.T.S. is a scientific founder of Immunai and receives research funding from Arsenal Biosciences.

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Auteurs

Xiao Huang (X)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Stephen T Ferris (ST)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Sunkyung Kim (S)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Mayank N K Choudhary (MNK)

Department of Genetics, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Julia A Belk (JA)

Department of Computer Science, Stanford University, Stanford, CA, USA.

Changxu Fan (C)

Department of Genetics, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Yanyan Qi (Y)

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Raki Sudan (R)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Yu Xia (Y)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Pritesh Desai (P)

Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Jing Chen (J)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Nghi Ly (N)

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Quanming Shi (Q)

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Prachi Bagadia (P)

Department of Oncology, Amgen, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

Tiantian Liu (T)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Martin Guilliams (M)

Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent 9000, Belgium.

Takeshi Egawa (T)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Marco Colonna (M)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Michael S Diamond (MS)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Theresa L Murphy (TL)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Ansuman T Satpathy (AT)

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Ting Wang (T)

Department of Genetics, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; McDonnell Genome Institute, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.

Kenneth M Murphy (KM)

Department of Pathology and Immunology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA. Electronic address: kmurphy@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Differential usage of transcriptional...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Differential usage of transcriptional...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Differential usage of transcriptional...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Differential usage of transcriptional...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Differential usage of transcriptional...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Differential usage of transcriptional...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Differential usage of transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Differential usage of transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Differential usage of transcriptional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Differential usage of transcriptional...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Differential usage of transcriptional...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Differential usage of transcriptional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Facteur de transcription Zeb2 › Differential usage of transcriptional...