Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile.
Clostridium difficile
Hanks kinase
anaerobes
cell division
cell wall
cell wall hydrolases
control of exportation
envelope homeostasis
kinases
peptidoglycan
phosphorylation
protein phosphorylation
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
18 05 2021
18 05 2021
Historique:
entrez:
19
5
2021
pubmed:
20
5
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Cell growth and division require a balance between synthesis and hydrolysis of the peptidoglycan (PG). Inhibition of PG synthesis or uncontrolled PG hydrolysis can be lethal for the cells, making it imperative to control peptidoglycan hydrolase (PGH) activity. The synthesis or activity of several key enzymes along the PG biosynthetic pathway is controlled by the Hanks-type serine/threonine kinases (STKs). In Gram-positive bacteria, inactivation of genes encoding STKs is associated with a range of phenotypes, including cell division defects and changes in cell wall metabolism, but only a few kinase substrates and associated mechanisms have been identified. We previously demonstrated that STK-PrkC plays an important role in cell division, cell wall metabolism, and resistance to antimicrobial compounds in the human enteropathogen
Identifiants
pubmed: 34006648
pii: mBio.00519-21
doi: 10.1128/mBio.00519-21
pmc: PMC8262956
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Peptidoglycan
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
N-Acetylmuramoyl-L-alanine Amidase
EC 3.5.1.28
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 Garcia-Garcia et al.
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