USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.


Journal

Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562

Informations de publication

Date de publication:
06 2021
Historique:
received: 24 08 2020
accepted: 23 04 2021
revised: 08 04 2021
pubmed: 20 5 2021
medline: 14 1 2022
entrez: 19 5 2021
Statut: ppublish

Résumé

The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a member of the so-called "death-from-cancer" signature predicting therapy failure in cancer patients. However, the importance and functional role of USP22 in different types and subtypes of cancer remain largely unknown. In the present study, we leveraged human cell lines and genetic mouse models to investigate the role of USP22 in HER2-driven breast cancer (HER2

Identifiants

pubmed: 34007022
doi: 10.1038/s41388-021-01814-5
pii: 10.1038/s41388-021-01814-5
pmc: PMC8195738
doi:

Substances chimiques

ERBB2 protein, human EC 2.7.10.1
Receptor, ErbB-2 EC 2.7.10.1
USP22 protein, mouse EC 3.4.19.12
Ubiquitin Thiolesterase EC 3.4.19.12
Usp22 protein, human EC 3.4.19.12

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4004-4018

Références

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Auteurs

Evangelos Prokakis (E)

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Anna Dyas (A)

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.
MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.

Regina Grün (R)

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Sonja Fritzsche (S)

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.
Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany.

Upasana Bedi (U)

Chromatin Remodeling Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 110067.

Zahra B Kazerouni (ZB)

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Robyn L Kosinsky (RL)

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.
Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Steven A Johnsen (SA)

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. johnsen.steven@mayo.edu.
Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. johnsen.steven@mayo.edu.

Florian Wegwitz (F)

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. fwegwit@gwdg.de.
Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany. fwegwit@gwdg.de.

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