Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
03
2021
revised:
11
04
2021
accepted:
16
04
2021
entrez:
19
5
2021
pubmed:
20
5
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Glucagon-like peptide 1 receptor agonists and dipeptidyl-peptidase 4 inhibitors are medications used for managing diabetes, mimicking the metabolic effects of incretin hormones. Recent evidence suggests that these medications have antioxidative potentials in the diabetic milieu. The pathophysiology of most diabetic complications involves oxidative stress. Therefore, if incretin-based antidiabetic medications can alleviate the free radicals involved in oxidative stress, they can potentially provide further therapeutic effects against diabetic complications. However, the molecular mechanisms by which these medications protect against oxidative stress are not fully understood. In the current review, we discuss the potential molecular mechanisms behind these pharmacologic agents' antioxidative properties.
Identifiants
pubmed: 34007411
doi: 10.1155/2021/9959320
pmc: PMC8099522
doi:
Substances chimiques
Antioxidants
0
Dipeptidyl-Peptidase IV Inhibitors
0
Glucagon-Like Peptide-1 Receptor
0
Hypoglycemic Agents
0
Incretins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9959320Informations de copyright
Copyright © 2021 Habib Yaribeygi et al.
Déclaration de conflit d'intérêts
The authors declare to have no conflict of interest in this study.
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