The density of calretinin striatal interneurons is decreased in 6-OHDA-lesioned mice.
Basal ganglia
Calcium binding protein
Dopamine
Nucleus accumbens
Parkinson’s disease
Striatum
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
08
12
2020
accepted:
08
05
2021
pubmed:
22
5
2021
medline:
15
12
2021
entrez:
21
5
2021
Statut:
ppublish
Résumé
Interneurons play a significant role in the functional organization of the striatum and some of them display marked plastic changes in dopamine-depleted conditions. Here, we applied immunohistochemistry on brain sections from 6-hydroxydopamine (6-OHDA) mouse model of Parkinson's disease and sham animals to characterize the regional distribution and the morphological and neurochemical changes of striatal interneurons expressing the calcium-binding protein calretinin (CR). Two morphological subtypes of calretinin-immunostained (CR +) interneurons referred, respectively, as small- and medium-sized CR + interneurons were detected in 6-OHDA- and sham-lesioned animals. The small cells (9-12 µm) prevail in the anterior and dorsal striatal regions; they stain intensely for CR and display a single slightly varicose and moderately arborized process. The medium-sized CR + interneurons (15-20 µm) are more numerous than the small CR + cells and rather uniformly distributed within the striatum; they stain weakly for CR and display 2-3 long, slightly varicose and poorly branched dendrites. The density of medium CR + interneurons is significantly decreased in the dopamine-depleted striatum (158 ± 15 neurons/mm
Identifiants
pubmed: 34018041
doi: 10.1007/s00429-021-02298-5
pii: 10.1007/s00429-021-02298-5
doi:
Substances chimiques
Calbindin 2
0
Calcium-Binding Proteins
0
Oxidopamine
8HW4YBZ748
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1879-1891Subventions
Organisme : Institute of Neurosciences, Mental Health and Addiction (CA)
ID : CIHR 153068
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : NSERC 06264
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 522690
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