Allium
/ chemistry
Animals
Connective Tissue Growth Factor
/ genetics
Diabetes Mellitus, Experimental
/ drug therapy
Diabetic Nephropathies
/ drug therapy
Down-Regulation
/ drug effects
Gene Expression
/ drug effects
Male
Plant Extracts
/ chemistry
Rats
Rats, Wistar
Receptor for Advanced Glycation End Products
/ genetics
Allium jesdianum
CTGF
RAGE
diabetic nephropathy
oxidative stress
Journal
Hormone molecular biology and clinical investigation
ISSN: 1868-1891
Titre abrégé: Horm Mol Biol Clin Investig
Pays: Germany
ID NLM: 101538885
Informations de publication
Date de publication:
20 May 2021
20 May 2021
Historique:
received:
24
09
2020
accepted:
19
01
2021
pubmed:
22
5
2021
medline:
29
12
2021
entrez:
21
5
2021
Statut:
epublish
Résumé
Diabetic nephropathy is one of the major complications of diabetes, the use of medicinal plants is increasing due to fewer side effects. This study was designed to examine antidiabetic effects of In this study, we randomly divided 24 rats into four groups with six rats in each group as follows: Cnt group: normal control receiving normal saline, Dibt group: diabetic control receiving normal saline daily, Dibt + The results showed that in the diabetic group the FBG and serum urea, creatinine and expression of kidney CTGF and RAGE genes and the levels of SOD and MDA significantly increased and serum albumin significantly decreased compared to the Cnt group (p<0.001). Administration of The results of this study showed that administration of
Identifiants
pubmed: 34018385
pii: hmbci-2020-0072
doi: 10.1515/hmbci-2020-0072
doi:
Substances chimiques
Plant Extracts
0
Receptor for Advanced Glycation End Products
0
Connective Tissue Growth Factor
139568-91-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-174Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
Références
Lim, AK. Diabetic nephropathy-complications and treatment. Int J Nephrol Renovasc Dis 2014;7:361–81. https://doi.org/10.2147/ijnrd.s40172.
Yee, J. Diabetic kidney disease: chronic kidney disease and diabetes. Diabetes Spectr 2008;21:8. https://doi.org/10.2337/diaspect.21.1.8.
Dabla, PK. Renal function in diabetic nephropathy. World J Diabetes 2010;1:48–56. https://doi.org/10.4239/wjd.v1.i2.48.
Kashihara, N, Haruna, Y, Kondeti, VK, Kanwar, YS. Oxidative stress in diabetic nephropathy. Curr Med Chem 2010;17:4256–69. https://doi.org/10.2174/092986710793348581.
Mason, RM. Connective tissue growth factor (CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it? J Cell Commun Signal 2009;3:95–104. https://doi.org/10.1007/s12079-009-0038-6.
Wang, S, Li, B, Li, C, Cui, W, Miao, L. Potential renoprotective agents through inhibiting CTGF/CCN2 in diabetic nephropathy. J Diabetes Res 2015;2015:962383. https://doi.org/10.1155/2015/962383.
Sanajou, D, Ghorbani Haghjo, A, Argani, H, Aslani, S. AGE-RAGE axis blockade in diabetic nephropathy: current status and future directions. Eur J Pharmacol 2018;833:158–64. https://doi.org/10.1016/j.ejphar.2018.06.001.
Singh, VP, Bali, A, Singh, N, Jaggi, AS. Advanced glycation end products and diabetic complications. Kor J Physiol Pharmacol 2014;18:1–14. https://doi.org/10.4196/kjpp.2014.18.1.1.
Yamagishi, S-I, Matsui, T. Advanced glycation end products, oxidative stress and diabetic nephropathy. Oxid Med Cell Longev 2010;3:101–8. https://doi.org/10.4161/oxim.3.2.11148.
Ott, C, Jacobs, K, Haucke, E, Navarrete Santos, A, Grune, T, Simm, A. Role of advanced glycation end products in cellular signaling. Redox Biol 2014;2:411–29. https://doi.org/10.1016/j.redox.2013.12.016.
Rines, AK, Sharabi, K, Tavares, CDJ, Puigserver, P. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nat Rev Drug Discov 2016;15:786–804. https://doi.org/10.1038/nrd.2016.151.
Ekor, M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014;4:177. https://doi.org/10.3389/fphar.2013.00177.
Marrelli, M, Amodeo, V, Statti, G, Conforti, F. Biological properties and bioactive components of Allium cepa L.: focus on potential benefits in the treatment of obesity and related comorbidities. Molecules 2018;24:119. https://doi.org/10.3390/molecules24010119.
Kim, S, Kim, DB, Jin, W, Park, J, Yoon, W, Lee, Y, et al.. Comparative studies of bioactive organosulphur compounds and antioxidant activities in garlic (Allium sativum L.), elephant garlic (Allium ampeloprasum L.) and onion (Allium cepa L.). Nat Prod Res 2018;32:1193–7. https://doi.org/10.1080/14786419.2017.1323211.
Sohrabinezhad, Z, Dastan, D, Asl, SS, Nili-Ahmadabadi, A. Allium jesdianum extract improve acetaminophen-induced hepatic failure through inhibition of oxidative/nitrosative stress. J Pharmacopuncture 2019;22:239–47. https://doi.org/10.3831/KPI.2019.22.032.
Mehrabadi, ME, Salemi, Z, Babaie, S, Panahi, M. Effect of biochanin A on retina levels of vascular endothelial growth factor, tumor necrosis factor-alpha and interleukin-1beta in rats with streptozotocin-induced diabetes. Can J Diabetes 2018;42:639–44. https://doi.org/10.1016/j.jcjd.2018.03.008.
Nasiri, A, Ziamajidi, N, Abbasalipourkabir, R, Goodarzi, MT, Saidijam, M, Behrouj, H, et al.. Beneficial effect of aqueous garlic extract on inflammation and oxidative stress status in the kidneys of type 1 diabetic rats. Indian J Clin Biochem 2017;32:329–36. https://doi.org/10.1007/s12291-016-0621-6.
Ghasemi, H, Einollahi, B, khiripour, N, Hosseini-Zijoud, S-R, Farhadiannezhad, M. Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes. Iran J Basic Med Sci 2019;22:376–83. https://doi.org/10.22038/ijbms.2019.31922.7674.
Oyedemi, SO, Adewusi, EA, Aiyegoro, OA, Akinpelu, DA. Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin-induced diabetic Wistar rats. Asian Pac J Trop Biomed 2011;1:353–8. https://doi.org/10.1016/S2221-1691(11)60079-8.
Alaee, M, Akbari, A, Karami, H, Salemi, Z, Amri, J, Panahi, M. Antidiabetic and protective effects of Scrophularia striata ethanolic extract on diabetic nephropathy via suppression of RAGE and S100A8 expression in kidney tissues of streptozotocin-induced diabetic rats. J Basic Clin Physiol Pharmacol 2020;31. https://doi.org/10.1515/jbcpp-2019-0186.
Roh, S-S, Kwon, OJ, Yang, JH, Kim, YS, Lee, SH, Jin, J-S, et al.. Allium hookeri root protects oxidative stress-induced inflammatory responses and β-cell damage in pancreas of streptozotocin-induced diabetic rats. BMC Complement Altern Med 2016;16:63. https://doi.org/10.1186/s12906-016-1032-1.
Zolfaghari, B, Shokoohinia, Y, Ramezanlou, P, Sadeghi, A, Mahmoudzadeh, M, Minaiyan, M. Effects of methanolic and butanolic fractions of Allium elburzense Wendelbo bulbs on blood glucose level of normal and STZ-induced diabetic rats. Res Pharm Sci 2012;7:201–7.
Chang, W-C, Wu, JS-B, Chen, C-W, Kuo, P-L, Chien, H-M, Wang, Y-T, et al.. Protective effect of vanillic acid against hyperinsulinemia, hyperglycemia and hyperlipidemia via alleviating hepatic insulin resistance and inflammation in high-fat diet (HFD)-Fed rats. Nutrients 2015;7:9946–59. https://doi.org/10.3390/nu7125514.
Matboli, M, Eissa, S, Ibrahim, D, Hegazy, MGA, Imam, SS, Habib, EK. Caffeic acid attenuates diabetic kidney disease via modulation of autophagy in a high-fat diet/streptozotocin- induced diabetic rat. Sci Rep 2017;7:2263. https://doi.org/10.1038/s41598-017-02320-z.
Yusuf, M, Nasiruddin, M, Sultana, N, Akhtar, J, Khan, MI, Ahmad, M. Regulatory mechanism of caffeic acid on glucose metabolism in diabetes. Res J Pharm Technol 2019;12:4735–40. https://doi.org/10.5958/0974-360x.2019.00816.3.
Asmat, U, Abad, K, Ismail, K. Diabetes mellitus and oxidative stress-a concise review. Saudi Pharmaceut J 2016;24:547–53. https://doi.org/10.1016/j.jsps.2015.03.013.
Matough, FA, Budin, SB, Hamid, ZA, Alwahaibi, N, Mohamed, J. The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ Med J 2012;12:5–18. https://doi.org/10.12816/0003082.
Ni, Z, Guo, L, Liu, F, Olatunji, OJ, Yin, M. Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and inflammation in high fat diet/streptozotocin treated rats. Biomed Pharmacother 2019;112:108678. https://doi.org/10.1016/j.biopha.2019.108678.
Beretta, HV, Bannoud, F, Insani, M, Berli, F, Hirschegger, P, Galmarini, CR, et al.. Relationships between bioactive compound content and the antiplatelet and antioxidant activities of six allium vegetable species. Food Technol Biotechnol 2017;55:266–75. https://doi.org/10.17113/ftb.55.02.17.4722.
Andersen, S, van Nieuwenhoven, FA, Tarnow, L, Rossing, P, Rossing, K, Wieten, L, et al.. Reduction of urinary connective tissue growth factor by Losartan in type 1 patients with diabetic nephropathy. Kidney Int 2005;67:2325–9. https://doi.org/10.1111/j.1523-1755.2005.00337.x.
Gojo, A, Utsunomiya, K, Taniguchi, K, Yokota, T, Ishizawa, S, Kanazawa, Y, et al.. The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. Eur J Pharmacol 2007;568:242–7. https://doi.org/10.1016/j.ejphar.2007.04.011.
Han, KH, Kang, YS, Han, SY, Jee, YH, Lee, MH, Han, JY, et al.. Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats. Kidney Int 2006;70:111–20. https://doi.org/10.1038/sj.ki.5000438.
Li, G-S, Jiang, W-L, Yue, X-D, Qu, G-W, Tian, J-W, Wu, J, et al.. Effect of astilbin on experimental diabetic nephropathy in vivo and in vitro. Planta Med 2009;75:1470–5. https://doi.org/10.1055/s-0029-1185802.