Effects of endocrine-disrupting chemicals on hypothalamic oxytocin and vasopressin systems.
Aroclor 1221
endocrine disrupting chemicals (EDCs)
oxytocin
paraventricular nucleus
polychlorinated biphenyls (PCBs)
supraoptic nucleus
vasopressin
Journal
Journal of experimental zoology. Part A, Ecological and integrative physiology
ISSN: 2471-5646
Titre abrégé: J Exp Zool A Ecol Integr Physiol
Pays: United States
ID NLM: 101710204
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
29
04
2021
received:
05
03
2021
accepted:
30
04
2021
pubmed:
22
5
2021
medline:
1
2
2022
entrez:
21
5
2021
Statut:
ppublish
Résumé
Exposures to endocrine disrupting chemicals (EDCs) perturb hormonal systems. EDCs are particularly problematic when exposure happens in the fetus and infant due to the high sensitivity of developing organisms to hormone actions. Previous work has shown that prenatal polychlorinated biphenyl (PCB) exposure disrupts hypothalamic development, reproductive physiology, mate preference behavior, and social behaviors in a sexually dimorphic manner. Based on evidence that EDCs perturb social behaviors in rodents, we examined effects of PCBs on the neuropeptides oxytocin (OXT) and vasopressin (AVP) that are involved in regulating these behaviors. Rats were exposed prenatally (gestational days 16 and 18) to the weakly estrogenic PCB mixture Aroclor 1221 (0.5 or 1 mg/kg), to estradiol benzoate (EB, a positive control), or to the vehicle (3% dimethyl sulfoxide). In adult (~P90) brains, we counted immunolabeled oxytocin and vasopressin cell numbers in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus. EDCs did not change absolute numbers of oxytocin or vasopressin cells in either region, although there were some modest shifts in the rostral-caudal distribution. Second, expression of genes for these nonapeptides (Oxt, Avp), their receptors (Oxtr, Avpr1a), and the estrogen receptor beta (Esr2), was determined by qPCR. In the PVN, there were dose-dependent effects of PCBs in males (Oxt, Oxtr), and effects of EB in females (Avp, Esr2). In the SON, Oxt, and Esr2 were affected by treatments in males. These changes to protein and gene expression caused by prenatal treatments suggest that transcriptional and posttranscriptional mechanisms play roles in mediating how EDCs reprogram hypothalamic development.
Identifiants
pubmed: 34018699
doi: 10.1002/jez.2475
pmc: PMC8606018
mid: NIHMS1705242
doi:
Substances chimiques
Endocrine Disruptors
0
Vasopressins
11000-17-2
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-87Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES023254
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029464
Pays : United States
Organisme : NIEHS NIH HHS
ID : ES023254
Pays : United States
Organisme : NIEHS NIH HHS
ID : ES029464
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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