2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 05 2021
21 05 2021
Historique:
received:
16
06
2020
accepted:
20
04
2021
entrez:
22
5
2021
pubmed:
23
5
2021
medline:
12
6
2021
Statut:
epublish
Résumé
High-yielding and selective prebiotic syntheses of RNA and DNA nucleotides involve UV irradiation to promote the key reaction steps and eradicate biologically irrelevant isomers. While these syntheses were likely enabled by UV-rich prebiotic environment, UV-induced formation of photodamages in polymeric nucleic acids, such as cyclobutane pyrimidine dimers (CPDs), remains the key unresolved issue for the origins of RNA and DNA on Earth. Here, we demonstrate that substitution of adenine with 2,6-diaminopurine enables repair of CPDs with yields reaching 92%. This substantial self-repairing activity originates from excellent electron donating properties of 2,6-diaminopurine in nucleic acid strands. We also show that the deoxyribonucleosides of 2,6-diaminopurine and adenine can be formed under the same prebiotic conditions. Considering that 2,6-diaminopurine was previously shown to increase the rate of nonenzymatic RNA replication, this nucleobase could have played critical roles in the formation of functional and photostable RNA/DNA oligomers in UV-rich prebiotic environments.
Identifiants
pubmed: 34021158
doi: 10.1038/s41467-021-23300-y
pii: 10.1038/s41467-021-23300-y
pmc: PMC8139960
doi:
Substances chimiques
Nucleic Acids
0
Nucleotides
0
Pyrimidine Dimers
0
2-Aminopurine
452-06-2
2,6-diaminopurine
49P95BAU4Z
RNA
63231-63-0
DNA
9007-49-2
Adenine
JAC85A2161
Banques de données
figshare
['10.6084/m9.figshare.14268056']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3018Subventions
Organisme : Medical Research Council
ID : MC_UP_A024_1009
Pays : United Kingdom
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