The type III secretion system effector EspO of enterohaemorrhagic Escherichia coli inhibits apoptosis through an interaction with HAX-1.
infection
mechanism of action
microbial-cell interaction
virulence
Journal
Cellular microbiology
ISSN: 1462-5822
Titre abrégé: Cell Microbiol
Pays: India
ID NLM: 100883691
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
13
05
2021
received:
16
12
2020
accepted:
17
05
2021
pubmed:
23
5
2021
medline:
14
1
2022
entrez:
22
5
2021
Statut:
ppublish
Résumé
Many enteric pathogens employ a type III secretion system (T3SS) to translocate effector proteins directly into the host cell cytoplasm, where they subvert signalling pathways of the intestinal epithelium. Here, we report that the anti-apoptotic regulator HS1-associated protein X1 (HAX-1) is an interaction partner of the T3SS effectors EspO of enterohaemorrhagic Escherichia coli (EHEC) and Citrobacter rodentium, OspE of Shigella flexneri and Osp1
Identifiants
pubmed: 34021690
doi: 10.1111/cmi.13366
pmc: PMC7613270
mid: EMS151439
doi:
Substances chimiques
Escherichia coli Proteins
0
Type III Secretion Systems
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13366Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K019007/1
Pays : United Kingdom
Organisme : Royal Government of Thailand
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.
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