Genes involved in phosphatidylcholine biosynthesis correlate with nuclear factor-κB in biliary tract cancer patients: Evidence from

Adult Aged, 80 and over Biliary Tract Neoplasms / genetics Cell Nucleus / metabolism Female Humans Male Middle Aged NF-kappa B / metabolism Phosphatidylcholines / biosynthesis Proton Magnetic Resonance Spectroscopy
(1)H NMR spectroscopy Cancer related symptoms Choline containing phospholipid Chronic cholecystitis Gallbladder cancer Lipid metabolite

Journal

Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727

Informations de publication

Date de publication:
09 2021
Historique:
received: 11 03 2021
revised: 30 04 2021
accepted: 11 05 2021
pubmed: 24 5 2021
medline: 18 9 2021
entrez: 23 5 2021
Statut: ppublish

Résumé

Gallbladder cancer (GBC) is an aggressive malignancy of gastrointestinal tract. Due to uncontrolled growth, GBC cells rapidly synthesize biomolecules including lipids. The lipids are integral component of cell membrane with a wide range of cellular functions. In this study, we measured the clinicopathological features in 40 cases of histologically confirmed GBC and 16 cases of chronic cholecystitis (CC). The female to male ratio in the GBC and CC groups were 3.44:1 and 2.2:1, respectively. The GBC patients exhibited well to poorly differentiated tumor. In the CC group, all patients showed cholecystitis with no evidence of dysplasia or malignancy. The majority of GBC and CC patients reported pain. Using

Identifiants

DOI: 10.1016/j.bbalip.2021.158970 PMID: 34023500
pubmed: 34023500
pii: S1388-1981(21)00098-6
doi: 10.1016/j.bbalip.2021.158970
pii:
doi:

Substances chimiques

NF-kappa B 0
Phosphatidylcholines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

158970

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Anusmita Shekher (A)

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221 005, India.

Amit Kumar Tiwari (AK)

Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.

Nikee Awasthee (N)

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221 005, India.

Sumit Singh Verma (SS)

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221 005, India.

Vinod Kumar Dixit (VK)

Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.

Neeraj Sinha (N)

Centre of Bio-Medical Research, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India.

Subash Chandra Gupta (SC)

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221 005, India; Department of Biochemistry, All India Institute of Medical Sciences, Guwahati, India. Electronic address: sgupta@bhu.ac.in.
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India. Electronic address: puneetimsbhu@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genes involved in phosphatidylcholine...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Genes involved in phosphatidylcholine...
questionsmedicales.fr › Maladies de l'appareil digestif › Tumeurs de l'appareil digestif › Tumeurs des voies biliaires › Genes involved in phosphatidylcholine...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Genes involved in phosphatidylcholine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genes involved in phosphatidylcholine...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genes involved in phosphatidylcholine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Genes involved in phosphatidylcholine...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidylcholines › Genes involved in phosphatidylcholine...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du proton › Genes involved in phosphatidylcholine...