The disassembly of lipid droplets in Chlamydomonas.
Chlamydomonas reinhardtii
amphipathic helix
autophagy
lipase
nitrogen recovery
peroxisome
phosphatidylethanolamine
scaffold protein
Journal
The New phytologist
ISSN: 1469-8137
Titre abrégé: New Phytol
Pays: England
ID NLM: 9882884
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
22
03
2021
accepted:
07
05
2021
pubmed:
25
5
2021
medline:
22
7
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
Lipid droplets (LDs) are ubiquitous and specialized organelles in eukaryotic cells. Consisting of a triacylglycerol core surrounded by a monolayer of membrane lipids, LDs are decorated with proteins and have myriad functions, from carbon/energy storage to membrane lipid remodeling and signal transduction. The biogenesis and turnover of LDs are therefore tightly coordinated with cellular metabolic needs in a fluctuating environment. Lipid droplet turnover requires remodeling of the protein coat, lipolysis, autophagy and fatty acid β-oxidation. Several key components of these processes have been identified in Chlamydomonas (Chlamydomonas reinhardtii), including the major lipid droplet protein, a CXC-domain containing regulatory protein, the phosphatidylethanolamine-binding DTH1 (DELAYED IN TAG HYDROLYSIS1), two lipases and two enzymes involved in fatty acid β-oxidation. Here, we review LD turnover and discuss its physiological significance in Chlamydomonas, a major model green microalga in research on algal oil.
Substances chimiques
Triglycerides
0
Lipase
EC 3.1.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1359-1364Informations de copyright
© 2021 The Authors New Phytologist © 2021 New Phytologist Foundation.
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