Mouse Models of Kidney Fibrosis.
Hydronephrosis
IRI
Mouse model
UUO
Unilateral ischemia reperfusion
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
24
5
2021
pubmed:
25
5
2021
medline:
11
8
2021
Statut:
ppublish
Résumé
Chronic kidney disease (CKD) affects over 10% of the worldwide population and kidney fibrosis is a main driver of CKD and considered a therapeutic target. The mechanisms leading to kidney fibrosis are highly complexed and can be best studied in rodent models. Here we describe the most commonly used kidney fibrosis models in mice, the unilateral ureteral obstruction (UUO) model and the ischemia reperfusion injury (IRI) model. Both models are easy to learn and can be applied in animals of different age, sex, and strain.
Identifiants
pubmed: 34028752
doi: 10.1007/978-1-0716-1382-5_22
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
323-338Références
Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider RK, Humphreys BD (2018) Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis. JCI Insight 3(9):e99561. https://doi.org/10.1172/jci.insight.99561
doi: 10.1172/jci.insight.99561
pmcid: 6012505
Kramann R, Wongboonsin J, Chang-Panesso M, Machado FG, Humphreys BD (2017) Gli1
doi: 10.1681/ASN.2016030297
Rabe M, Schaefer F (2016) Non-transgenic mouse models of kidney disease. Nephron 133(1):53–61. https://doi.org/10.1159/000445171
doi: 10.1159/000445171
pubmed: 27212380
Martínez-Klimova E, Aparicio-Trejo OE, Tapia E, Pedraza-Chaverri J (2019) Unilateral ureteral obstruction as a model to investigate fibrosis-attenuating treatments. Biomol Ther 9(4):141. https://doi.org/10.3390/biom9040141
doi: 10.3390/biom9040141
Heung M, Chawla LS (2014) Acute kidney injury: gateway to chronic kidney disease. Nephron Clin Pract 127(1–4):30–34. https://doi.org/10.1159/000363675
doi: 10.1159/000363675
pubmed: 25343817
Bonventre JV, Yang L (2011) Cellular pathophysiology of ischemic acute kidney injury. JCI (121):4210–4221
Hesketh EE, Czopek A, Clay M, Borthwick G, Ferenbach D, Kluth D, Hughes J (2014) Renal ischaemia reperfusion injury: a mouse model of injury and regeneration. J Vis Exp:88. https://doi.org/10.3791/51816
Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf O, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD (2015) Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. J Clin Invest 125(8):2935–2951. https://doi.org/10.1172/JCI74929
doi: 10.1172/JCI74929
pubmed: 26193634
pmcid: 4563736
Li L, Kang H, Zhang Q, D'Agati VD, Al-Awqati Q, Lin F (2019) FoxO3 activation in hypoxic tubules prevents chronic kidney disease. J Clin Invest 129(6):2374–2389. https://doi.org/10.1172/JCI122256
doi: 10.1172/JCI122256
pubmed: 30912765
pmcid: 6541430
Sauer M, Fleischmann T, Lipiski M, Arras M, Jirkof P (2016) Buprenorphine via drinking water and combined oral-injection protocols for pain relief in mice. Appl Anim Behav Sci 185:103–112. https://doi.org/10.1016/j.applanim.2016.09.009
doi: 10.1016/j.applanim.2016.09.009
Russell WMS, Burch RL (1959) The principles of humane experimental technique. Methuen, London, pp 69–154
Ham A, Kim M, Kim JY, Brown KM, Yeh J, D’Agati VD, Lee HT (2013) Critical role of interleukin-11 in isoflurane-mediated protection against ischemic acute kidney injury in mice. Anesthesiology 119(6):1389–1401. https://doi.org/10.1097/ALN.0b013e3182a950da
doi: 10.1097/ALN.0b013e3182a950da
pubmed: 24037316
Aufhauser DD Jr, Wang Z, Murken DR, Bhatti TR, Wang Y, Ge G, Redfield RR 3rd, Abt PL, Wang L, Svoronos N, Thomasson A, Reese PP, Hancock WW, Levine MH (2016) Improved renal ischemia tolerance in females influences kidney transplantation outcomes. J Clin Invest 126(5):1968–1977. https://doi.org/10.1172/JCI84712
doi: 10.1172/JCI84712
pubmed: 27088798
pmcid: 4855926
Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Decoding myofibroblast origins in human kidney fibrosis. Nature. 2021 Jan;589(7841):281–286. https://doi.org/10.1038/s41586-020-2941-1