Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype.
Aminoglycosides
/ adverse effects
Anti-Bacterial Agents
/ adverse effects
Clinical Decision-Making
Genotype
Hearing Loss, Sensorineural
/ chemically induced
Humans
Ototoxicity
Patient Safety
Pharmacogenetics
Pharmacogenomic Testing
Pharmacogenomic Variants
Predictive Value of Tests
RNA, Ribosomal
/ genetics
Risk Assessment
Risk Factors
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
15
03
2021
accepted:
17
05
2021
pubmed:
26
5
2021
medline:
22
2
2022
entrez:
25
5
2021
Statut:
ppublish
Résumé
Aminoglycosides are widely used antibiotics with notable side effects, such as nephrotoxicity, vestibulotoxicity, and sensorineural hearing loss (cochleotoxicity). MT-RNR1 is a gene that encodes the 12s rRNA subunit and is the mitochondrial homologue of the prokaryotic 16s rRNA. Some MT-RNR1 variants (i.e., m.1095T>C; m.1494C>T; m.1555A>G) more closely resemble the bacterial 16s rRNA subunit and result in increased risk of aminoglycoside-induced hearing loss. Use of aminoglycosides should be avoided in individuals with an MT-RNR1 variant associated with an increased risk of aminoglycoside-induced hearing loss unless the high risk of permanent hearing loss is outweighed by the severity of infection and safe or effective alternative therapies are not available. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of aminoglycosides based on MT-RNR1 genotype (updates at https://cpicpgx.org/guidelines/ and www.pharmgkb.org).
Identifiants
pubmed: 34032273
doi: 10.1002/cpt.2309
pmc: PMC8613315
mid: NIHMS1752666
doi:
Substances chimiques
Aminoglycosides
0
Anti-Bacterial Agents
0
RNA, Ribosomal
0
RNA, ribosomal, 12S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
366-372Subventions
Organisme : NHGRI NIH HHS
ID : U24 HG010615
Pays : United States
Organisme : PharmGKB
Organisme : NCATS NIH HHS
ID : TL1 TR001858
Pays : United States
Organisme : American Foundation for Pharmaceutical Education
Organisme : Rho Chi Society
Organisme : NIDCD NIH HHS
ID : R01 DC016680
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG010135
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC012049
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC002842
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017955
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC004555
Pays : United States
Organisme : NIHR BRC
ID : IS-BRC-1215-20007
Organisme : NIDCD NIH HHS
ID : R56 DC004555
Pays : United States
Informations de copyright
© 2021 The Authors. Clinical Pharmacology & Therapeutics © 2021 American Society for Clinical Pharmacology and Therapeutics.
Références
J Antimicrob Chemother. 2020 Feb 1;75(2):458-465
pubmed: 31691817
Antimicrob Agents Chemother. 1997 Jan;41(1):184-7
pubmed: 8980777
Infect Control Hosp Epidemiol. 2017 Sep;38(9):1039-1047
pubmed: 28758610
PLoS One. 2020 Jul 30;15(7):e0236864
pubmed: 32730359
Clin Infect Dis. 2011 Mar 1;52(5):e103-20
pubmed: 21292654
Curr Urol Rep. 2018 Aug 09;19(10):78
pubmed: 30094687
J Laryngol Otol. 2004 Jul;118(7):546-50
pubmed: 15318963
Proc Natl Acad Sci U S A. 1986 Aug;83(16):6164-8
pubmed: 2426712
Pediatr Pulmonol. 2007 Apr;42(4):307-13
pubmed: 17352404
Am J Otol. 1995 Sep;16(5):653-7
pubmed: 8588672
Am J Otolaryngol. 1997 May-Jun;18(3):173-8
pubmed: 9164619
Mol Biol Rep. 2012 Jan;39(1):33-9
pubmed: 21533668
Am J Respir Crit Care Med. 2019 Nov 15;200(10):e93-e142
pubmed: 31729908
Data Brief. 2018 Mar 12;18:16-21
pubmed: 29896485
J Laryngol Otol. 2005 Jan;119(1):48-50
pubmed: 15807966
Euro Surveill. 2004 Dec 15;9(12):E9-10
pubmed: 15677845
Mayo Clin Proc. 2004 Sep;79(9):1185-91
pubmed: 15357042
BMJ Open. 2012 Jan 05;2:e000411
pubmed: 22223843
Hum Mutat. 2020 Dec;41(12):2028-2057
pubmed: 32906214
Laryngoscope. 1997 Apr;107(4):483-90
pubmed: 9111378
Am J Hum Genet. 1998 Jan;62(1):27-35
pubmed: 9490575
J Med Genet. 2000 Jan;37(1):38-40
pubmed: 10633132
Bioorg Med Chem Lett. 2002 Aug 19;12(16):2241-4
pubmed: 12127547
Cancer. 1984 Apr 1;53(7):1502-6
pubmed: 6365302
Sci Rep. 2014 Feb 13;4:4089
pubmed: 24522485
Antimicrob Agents Chemother. 2000 Dec;44(12):3249-56
pubmed: 11083623
Laryngorhinootologie. 1994 Jun;73(6):331-7
pubmed: 8060454
Clin Microbiol Rev. 2020 Apr 29;33(3):
pubmed: 32349999
Turk J Med Sci. 2019 Mar 21;49(2):514-518
pubmed: 30893980
Chest. 2002 Jul;122(1):219-26
pubmed: 12114362
Hum Genet. 2005 Jun;117(1):9-15
pubmed: 15841390
BMC Pediatr. 2014 Aug 26;14:210
pubmed: 25155176
J Transl Med. 2011 Jan 04;9:4
pubmed: 21205314
Clin Infect Dis. 2020 Aug 14;71(4):905-913
pubmed: 32797222
J Med Genet. 2003 Aug;40(8):632-6
pubmed: 12920080
Clin Infect Dis. 2014 May;58(10):1439-48
pubmed: 24501388
Pediatrics. 2011 Sep;128(3):595-610
pubmed: 21873693
Pharmacotherapy. 2003 Apr;23(4):543-5
pubmed: 12680485
Int J Antimicrob Agents. 2020 Mar;55(3):105839
pubmed: 31704215
Clin J Am Soc Nephrol. 2012 Aug;7(8):1249-56
pubmed: 22700884
J Clin Pharmacol. 1994 Mar;34(3):255-9
pubmed: 8021334
Perit Dial Int. 2014 Mar-Apr;34(2):219-26
pubmed: 24385334
Antimicrob Agents Chemother. 2009 Nov;53(11):4612-8
pubmed: 19687236
Transpl Infect Dis. 2009 Oct;11(5):467-70
pubmed: 19638004
Am J Otolaryngol. 2019 May - Jun;40(3):456-458
pubmed: 30910434
Int J Pediatr Otorhinolaryngol. 2015 Nov;79(11):1915-9
pubmed: 26384832
Neurology. 1997 Feb;48(2):453-6
pubmed: 9040738
Nature. 2014 Apr 24;508(7497):469-76
pubmed: 24759409
Pediatrics. 2007 Oct;120(4):898-921
pubmed: 17908777
J Urol. 2006 May;175(5):1861-4
pubmed: 16600780
Biochemistry. 1997 Oct 7;36(40):12323-8
pubmed: 9315872
Sci Transl Med. 2015 Jul 29;7(298):298ra118
pubmed: 26223301
Antimicrob Agents Chemother. 2010 May;54(5):1742-8
pubmed: 20160050
J Clin Microbiol. 2017 Dec 26;56(1):
pubmed: 29070654
N Engl J Med. 1960 Feb 25;262:380-5
pubmed: 14412744